AUTOINFLAMMATORY DISEASES IN CHILDREN: NEW CHALLENGES
DOI:
https://doi.org/10.52340/jecm.2025.06.36Keywords:
autoinflammatory, diseases, children, new challenges, PFAFA, FMFAbstract
Autoinflammatory diseases are a significant challenge for pediatricians due to polymorphic clinical manifestations and complex pathogenesis. Autoinflammatory diseases are characterized by fever attacks of varying duration, and clinical manifestations such as abdominal pain, lymphadenopathy, polyserositis, arthritis, etc. Despite the variety of clinical manifestations, there are several common characteristics, similarities to clinical symptoms, which complicate the differential diagnosis of autoinflammatory diseases. Diagnosing autoinflammatory diseases such as PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and adenitis) and FMF (Familial Mediterranean Fever) in children presents significant difficulties due to overlapping symptoms and variability of genetic mutations.
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