EFFECT OF IRON DEFICIENCY CORRECTION ON HEART FAILURE  PATIENT’S OUTCOMES

DAVID IOSEBASHVILI; SHALVA PETRIASHVILI; NANA LOLASHVILI; ANA PETRIASHVILI; IRMA MAMATSASHVILI

doi:10.52340/jecm.2022.06.17

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2026-01-29

EFFECT OF IRON DEFICIENCY CORRECTION ON HEART FAILURE PATIENT’S OUTCOMES

Authors

DAVID IOSEBASHVILI
SHALVA PETRIASHVILI
NANA LOLASHVILI
ANA PETRIASHVILI
IRMA MAMATSASHVILI

DOI:

https://doi.org/10.52340/jecm.2022.06.17

Keywords:

Heart failure, Iron deficiency, IV Ferrous (III), oral iron

Abstract

The aim of our study was to investigate the effect of intravenous and oral iron treatment on clinical parameters in Hart failure (HF) patients with iron deficiency (ID). We studied 78 adult patients with HF admitted to the hospital. All patients underwent a standardized clinical evaluation. Blood samples were obtained for: full blood count, serum iron concentration, ferritin, creatinine, and eGFR. Assessment of exercise capacity was performed by a 6-min walk test (6-MWT). Quality of life was studied using the Minnesota Quality of Life Questionnaire. Patients were divided in to two groups: 50 patients (group 1) received IV Ferrous (III) hydroxide sucrose complex (Venofer) 5ml/100mg; 28 patients (group 2) – controlled group. Treatment duration was 7.8±0.4 days in hospital. After discharge from the clinic, patients continued treatment with oral iron for 3 months. After 3 months patients were assessed again. In our study, iron treatment has been shown to improve clinically significant anemia and NYHA functional class. It also improved renal function and levels of NT-proBNP, but differences between two groups were not clinically significant. 6-minute walking distance test and quality of life were significantly improved in the iron treatment group. A heart failure iron treatment service can be set up as an independent or as an integrated service within heart failure care. All patients with HF should be routinely tested for serum iron and serum ferritin concentrations in addition to the usual blood tests. Intravenous Iron treatment is safe and can be used in hospital treatment in unstable and symptomatic patients. Oral Iron treatment can be used for long-term outpatient treatment.

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References

Georgian Society of Cardiologists. Diagnosis and management of chronic heart failure. 2006

Klip IT, Comin‐Colet J, Voors AA, Ponikowski P, Enjuanes C, Banasiak W, Lok DJ, Rosentryt P, Torrens A, Polonski L, van Veldhuisen DJ, van der Meer P, Jankowska EA. Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J 2013; 165: 575–582 e3.

Von Haehling S, Gremmler U, Krumm M, Mibach F, Schön N, Taggeselle J, Dahm JB, Angermann CE. Prevalence and clinical impact of iron deficiency and anaemia among outpatients with chronic heart failure: the PrEP Registry. Clin Res Cardiol 2017; 106: 436–443.

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Enjuanes C, Klip IT, Bruguera J, Cladellas M, Ponikowski P, Banasiak W, vanVeldhuisen DJ, van der Meer P, Jankowska EA, Comin-Colet J. Iron deficiency and health-related quality of life in chronic heart failure: results from a multicenter European study. Int J Cardiol 2014; 174:268–275.

Jankowska EA, Rozentryt P, Witkowska A, Nowak J, Hartmann O, PonikowskaB, Borodulin-Nadzieja L, von Haehling S, Doehner W, Banasiak W, PolonskiL, Filippatos G, Anker SD, Ponikowski P. Iron deficiency predicts impaired exercise capacity in patients with systolic chronic heart failure. J Card Fail2011; 17:899–906.

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American College of Cardiology. Latest in cardiology. Studies Explore Use of Iron Supplements in Treating HF Patients.https://www.acc.org/latest-in-cardiology/articles/2016/11/10/15/58/wed-1145amet-ironout-effect-aha2016.

Beck-da-Silva L, Piardi D, Soder S, et al. IRONHF study: a randomized trial to assess the effects of iron in heart failure patients with anemia. Int J Cardiol 2013; 168:3439–42.

Kocyigit D, Gurses KM. Iron deficiency and its treatment in heart failure: indications and effect of prognosis. E-Journal of Cardiology Practice 2016; Available from: https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-14/Iron-deficiency-and-its-treatment-in-heart-failure-indications-and-effect-on-prognosis

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Published

2022-06-02

How to Cite

DAVID IOSEBASHVILI, SHALVA PETRIASHVILI, NANA LOLASHVILI, ANA PETRIASHVILI, & IRMA MAMATSASHVILI. (2022). EFFECT OF IRON DEFICIENCY CORRECTION ON HEART FAILURE PATIENT’S OUTCOMES . Experimental and Clinical Medicine Georgia, (4). https://doi.org/10.52340/jecm.2022.06.17

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EFFECT OF IRON DEFICIENCY CORRECTION ON HEART FAILURE PATIENT’S OUTCOMES

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