MODERN APPROACHES OF COLORECTAL CANCER MANAGEMENT
DOI:
https://doi.org/10.52340/jecm.2025.02.22Keywords:
CRC, TAMIS, IMRT, EGFR, ICAbstract
Colorectal cancer (CRC) is the third most common cancer worldwide, and the second most common cause of cancer-related death. Accordingly, there is ongoing research aiming to find new and improved treatment modalities for CRC that can increase survival and decrease overall morbidity and mortality. Current management strategies for CRC include surgery, radiotherapy, chemotherapy, and immunotherapy, in addition to their combination. Nevertheless, CRC management remains a major challenge. This review summarizes the most recent therapeutic approaches for CRC, with special emphasis on new strategies that are currently being studied and have great potential to improve the prognosis and lifespan of patients with CRC.
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Bretthauer M, Løberg M, Wieszczy P, Kalager M, Emilsson L, Garborg K, Rupinski M, Dekker E, Spaander M, Bugajski M, Holme Ø, Zauber AG, Pilonis ND, Mroz A, Kuipers EJ, Shi J, Hernán MA, Adami HO, Regula J, Hoff G, Kaminski MF NordICC Study Group. Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death. N Engl J Med. 2022;387:1547–1556. doi: 10.1056/NEJMoa2208375
Shinji S, Yamada T, Matsuda A, Sonoda H, Ohta R, Iwai T, Takeda K, Yonaga K, Masuda Y, Yoshida H. Recent Advances in the Treatment of Colorectal Cancer: A Review. J Nippon Med Sch. 2022;89:246–254. doi: 10.1272/jnms.JNMS.2022_89-310.
Poston GJ, Figueras J, Giuliante F, Nuzzo G, Sobrero AF, Gigot JF, Nordlinger B, Adam R, Gruenberger T, Choti MA, Bilchik AJ, Van Cutsem EJ, Chiang JM, D'Angelica MI. Urgent need for a new staging system in advanced colorectal cancer. J Clin Oncol. 2008;26:4828–4833. doi: 10.1200/JCO.2008.17.6453.
Blackmore AE, Wong MT, Tang CL. Evolution of laparoscopy in colorectal surgery: an evidence-based review. World J Gastroenterol. 2014;20:4926–4933. doi: 10.3748/wjg.v20.i17.4926
Kitano S, Inomata M, Mizusawa J, Katayama H, Watanabe M, Yamamoto S, Ito M, Saito S, Fujii S, Konishi F, Saida Y, Hasegawa H, Akagi T, Sugihara K, Yamaguchi T, Masaki T, Fukunaga Y, Murata K, Okajima M, Moriya Y, Shimada Y. Survival outcomes following laparoscopic versus open D3 dissection for stage II or III colon cancer (JCOG0404): a phase 3, randomised controlled trial. Lancet Gastroenterol Hepatol. 2017;2:261–268. doi: 10.1016/S2468-1253(16)30207-2
Matsuda T, Sumi Y, Yamashita K, Hasegawa H, Yamamoto M, Matsuda Y, Kanaji S, Oshikiri T, Nakamura T, Suzuki S, Kakeji Y. Optimal Surgery for Mid-Transverse Colon Cancer: Laparoscopic Extended Right Hemicolectomy Versus Laparoscopic Transverse Colectomy. World J Surg. 2018;42:3398–3404. doi: 10.1007/s00268-018-4612-z
Mirkin KA, Kulaylat AS, Hollenbeak CS, Messaris E. Robotic versus laparoscopic colectomy for stage I-III colon cancer: oncologic and long-term survival outcomes. Surg Endosc. 2018;32:2894–2901. doi: 10.1007/s00464-017-5999-6
Atallah S, Martin-Perez B, Albert M, deBeche-Adams T, Nassif G, Hunter L, Larach S. Transanal minimally invasive surgery for total mesorectal excision (TAMIS-TME): results and experience with the first 20 patients undergoing curative-intent rectal cancer surgery at a single institution. Tech Coloproctol. 2014;18:473–480. doi: 10.1007/s10151-013-1095-7
Arezzo A, Bonino MA, Ris F, Boni L, Cassinotti E, Foo DCC, Shum NF, Brolese A, Ciarleglio F, Keller DS, Rosati R, De Nardi P, Elmore U, Fumagalli Romario U, Jafari MD, Pigazzi A, Rybakov E, Alekseev M, Watanabe J, Vettoretto N, Cirocchi R, Passera R, Forcignanò E, Morino M. Intraoperative use of fluorescence with indocyanine green reduces anastomotic leak rates in rectal cancer surgery: an individual participant data analysis. Surg Endosc. 2020;34:4281–4290. doi: 10.1007/s00464-020-07735-w.
Luh JY, Albuquerque KV, Cheng C, Ermoian RP, Nabavizadeh N, Parsai H, Roeske JC, Weiss SE, Wynn RB, Yu Y, Rosenthal SA, Hartford A. ACR-ASTRO Practice Parameter for Image-guided Radiation Therapy (IGRT) Am J Clin Oncol. 2020;43:459–468. doi: 10.1097/COC.0000000000000697
Sharabi AB, Tran PT, Lim M, Drake CG, Deweese TL. Stereotactic radiation therapy combined with immunotherapy: augmenting the role of radiation in local and systemic treatment. Oncology (Williston Park) 2015;29:331–340
Lavrova E, Garrett MD, Wang YF, Chin C, Elliston C, Savacool M, Price M, Kachnic LA, Horowitz DP. Adaptive Radiation Therapy: A Review of CT-based Techniques. Radiol Imaging Cancer. 2023;5:e230011. doi: 10.1148/rycan.230011
Haque M, Shakil MS, Mahmud KM. The Promise of Nanoparticles-Based Radiotherapy in Cancer Treatment. Cancers (Basel) 2023;15 doi: 10.3390/cancers15061892
Vaios EJ, Wo JY. Proton beam radiotherapy for anal and rectal cancers. J Gastrointest Oncol. 2020;11:176–186. doi: 10.21037/jgo.2019.04.03
Mitin T, Zietman AL. Promise and pitfalls of heavy-particle therapy. J Clin Oncol. 2014;32:2855–2863. doi: 10.1200/JCO.2014.55.1945
Duarte D, Vale N. Combining repurposed drugs to treat colorectal cancer. Drug Discov Today. 2022;27:165–184. doi: 10.1016/j.drudis.2021.09.012
Padma VV. An overview of targeted cancer therapy. Biomedicine (Taipei) 2015;5:19. doi: 10.7603/s40681-015-0019-4
Neumann J, Wehweck L, Maatz S, Engel J, Kirchner T, Jung A. Alterations in the EGFR pathway coincide in colorectal cancer and impact on prognosis. Virchows Arch. 2013;463:509–523. doi: 10.1007/s00428-013-1450-0
Ros J, Rodríguez-Castells M, Saoudi N, Baraibar I, Salva F, Tabernero J, Élez E. Treatment of BRAF-V600E mutant metastatic colorectal cancer: new insights and biomarkers. Expert Rev Anticancer Ther. 2023;23:797–806. doi: 10.1080/14737140.2023.2236794
Koury J, Lucero M, Cato C, Chang L, Geiger J, Henry D, Hernandez J, Hung F, Kaur P, Teskey G, Tran A. Immunotherapies: Exploiting the Immune System for Cancer Treatment. J Immunol Res. 2018;2018:9585614. doi: 10.1155/2018/9585614.
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