DEMENTIA SEVERITY ASSESSED BY MINI MENTAL STATE EXAMINATION AND ITS METABOLIC CORRELATES

TAMAR LAZASHVILI; VERA KAPETIVADZE; TEIMURAZ SILAGADZE; ZVIAD MAGLAPHERIDZE; IRINA KAPETIVADZE

doi:10.52340/jecm.2025.02.12

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2026-01-29

DEMENTIA SEVERITY ASSESSED BY MINI MENTAL STATE EXAMINATION AND ITS METABOLIC CORRELATES

Authors

TAMAR LAZASHVILI Tbilisi State Medical University
VERA KAPETIVADZE Tbilisi State Medical University
TEIMURAZ SILAGADZE Tbilisi State Medical University
ZVIAD MAGLAPHERIDZE Tbilisi State Medical University
IRINA KAPETIVADZE Tbilisi State Medical University

DOI:

https://doi.org/10.52340/jecm.2025.02.12

Keywords:

Dementia, MMSE scale, Body Mass Index, Metabolism

Abstract

Objectives. The aim of our study was to identify the metabolic correlates of dementia severity assessed by Mini-Mental State Examination (MMSE) in patients with dementia and eating disorders.

Methods. Cross-sectional observational study was performed from 2020 to 2023 in palliative clinic “Palmedi” of Tbilisi State Medical University. The study group consisted of 77 patients with dementia (18 males, 59 females; mean age - 78.0 ± 11.1). Dementia was assessed by Mini-Mental State Examination (MMSE), and eating disorders assessed by Mini Nutritional Assessment (MNA) scale. Serum resistin levels, fasting plasma glucose (FPG) and insulin (FPI), C-peptide, parameters of lipid metabolism – total cholesterol (TC), triglycerides (TG), HDL-, LDL- and VLDL-cholesterol were measured and analyzed. Insulin resistance was assessed by HOMA model. BMI and waist circumference have been also measured. Correlation was assessed by Pearson coefficient (r).

Results. MMSE-score was significantly positively correlated with MNA-score (r=0.605, p<0.001), HDL-cholesterol levels (r=0.237, p=0.038), and BMI (r=0.258, p=0.023). The significant negative correlation was obtained between MMSE-score and age (r= -0.264, p=0.020), TG (r= -0.311, p=0.006), and resistin levels (r= -0.309, p=0.006). Correlation of MMSE-score with other studied parameters was not significant.

Conclusion. Dementia severity assessed by MMSE-score was significantly correlated with age, BMI, eating disorders assessed by MNA-score, TG and HDL-cholesterol, and resistin levels. So, it may be concluded that dementia is associated with impaired metabolism.

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References

Fostinelli S, De Amicis R, Leone A, Giustizieri V, et al. Eating Behavior in Aging and Dementia: The Need for a Comprehensive Assessment. Front Nutr. 2020; 7:604488. doi: 10.3389/fnut.2020.604488.

https://www.who.int/news-room/fact-sheets/detail/dementia

Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA 2002;288:1475–83. 10.1001/jama.288.12.1475.

Petersson SD, Philippou E. Mediterranean diet, cognitive function, and dementia: a systematic review of the evidence. Adv Nutr. 2016;7:889–904. 10.3945/an.116.012138.

Kivipelto M, Mangialasche F, Ngandu T. Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nat Rev Neurol. 2018;14:653–66. 10.1038/s41582-018-0070-3.

Lehtisalo J, Levälahti E, Lindström J, Hänninen T, et al. Dietary changes and cognition over 2 years within a multidomain intervention trial-the finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER). Alzheimers Dement. 2019;15:410–7. 10.1016/j.jalz.2018.10.001.

Marijn Stok F, Renner B, Allan J, Boeing H, et al. dietary behavior: an interdisciplinary conceptual analysis and taxonomy. Front Psychol. 2018;9:1689. 10.3389/fpsyg.2018.01689.

LaCaille L. Eating behavior. In: Gellman MD, Turner JR, editors. Encyclopedia of Behavioral Medicine. New York, NY: Springer New York; 2013. p. 641–642.

Yannakoulia M, Mamalaki E, Anastasiou CA, et al. Eating habits and behaviors of older people: where are we now and where should we go? Maturitas 2018;114:14–21. 10.1016/j.maturitas.2018.05.001.

Bales CW, Ritchie CS. Sarcopenia, weight loss, and nutritional frailty in the elderly. Annu Rev Nutr. 2002;22:309–23. 10.1146/annurev.nutr.22.010402.102715.

Ikeda M, Brown J, Holland AJ, Fukuhara R, Hodges JR. Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer's disease. J Neurol Neurosurg Psychiatr 2002;73:371–6. 10.1136/jnnp.73.4.371.

Soto M, Andrieu S, Gares V, Cesari M, Gillette-Guyonnet S, Cantet C, et al. Living alone with alzheimer's disease and the risk of adverse outcomes: results from the plan de Soin et d'Aide dans la maladie d'Alzheimer study. J Am Geriatr Soc. 2015;63:651–8. 10.1111/jgs.13347.

White H, Pieper C, Schmader K. The association of weight change in Alzheimer's disease with severity of disease and mortality: a longitudinal analysis. J Am Geriatr Soc. 1998;46:1223–7. 10.1111/j.1532-5415.1998.tb04537.x.

Gillette-Guyonnet S, Nourhashemi F, Andrieu S, de Glisezinski I, Ousset PJ, Riviere D, et al. Weight loss in Alzheimer disease. Am J Clin Nutr. 2000;71:637S-42S. 10.1093/ajcn/71.2.637s.

Craig D, Mirakhur A, Hart DJ, McIlroy SP, Passmore AP. A cross-sectional study of neuropsychiatric symptoms in 435 patients with Alzheimer's disease. Am J Geriatr Psychiatry 2005;13:460–8. 10.1097/00019442-200506000-00004.

Maurer K, Volk S, Gerbaldo H. Auguste D and Alzheimer's disease. Lancet 1997; 349:1546–9. 10.1016/S0140-6736(96)10203-8.

Vercruysse P, Vieau D, Blum D, Petersen A, Dupuis L. Hypothalamic alterations in neurodegenerative diseases and their relation to abnormal energy metabolism. Front Mol Neurosci. 2018;11:2. 10.3389/fnmol.2018.00002.

Hu X, Okamura N, Arai H, Higuchi M, Maruyama M, Itoh M, et al. Neuroanatomical correlates of low body weight in Alzheimer's disease: a PET study. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26:1285–9. 10.1016/S0278-5846(02)00291-9.

Grundman M, Corey-Bloom J, et al. Low body weight in Alzheimer's disease is associated with mesial temporal cortex atrophy. Neurology 1996;46:1585–91. 10.1212/WNL.46.6.1585.

Power DA, Noel J, Collins R, O'Neill D. Circulating leptin levels and weight loss in Alzheimer's disease patients. Dement Geriatr Cogn Disord. 2001;12:167–70. 10.1159/000051252.

Holscher C. Insulin signaling impairment in the brain as a risk factor in Alzheimer's disease. Front Aging Neurosci. 2019;11:88. 10.3389/fnagi.2019.00088.

Hiller AJ, Ishii M. Disorders of body weight, sleep and circadian rhythm as manifestations of hypothalamic dysfunction in Alzheimer's disease. Front Cell Neurosci. 2018;12:471. 10.3389/fncel.2018.00471.

Boccardi V, Ruggiero C, Patriti A, Marano L. Diagnostic Assessment and Management of Dysphagia in Patients with Alzheimer's Disease. J Alzheimers Dis. 2016;50(4):947-55. doi: 10.3233/JAD-150931.

Alagiakrishnan K, Bhanji RA, Kurian M. Evaluation and management of oropharyngeal dysphagia in different types of dementia: a systematic review. Arch Gerontol Geriatr. 2013;56(1):1-9. doi: 10.1016/j.archger.2012.04.011.

Y. Malekizadeh, A. Holiday, D. Redfearn, J. Ainge, G. Doherty, J. Harvey, A leptin fragment mirrors the cognitive enhancing and neuroprotective actions of leptin. Cereb. Cortex 2016;27(10):4769–4782.

W. Hu, D. Holtzman, et al, Alzheimer’s disease Neuroimaging Initiative, 2012. Plasma multianalyte profiling in mild cognitive impairment and Alzheimer’s disease, Neurology 2012;79:897–905.

S. Walter, M. Letiembre, Y. Liu, et al, Role of the toll-like receptor 4 inneuroinflammation in Alzheimer’s disease. Cell, Physiol. Biochem 2007;20:947–956.

M. Kizilarslanoğlu, O. Kara, Y. Yeşil, et al, Alzheimer disease, inflammation, and novel inflammatory marker: resistin, Turkish J. Med. Sci. 2015;45:1040–1046.

Ismail Z, Rajji TK, Shulman KI. Brief cognitive screening instruments: an update. Int J Geriatr Psychiatry. 2010;25:111–120.

Kaiser MJ, Bauer JM, et al. Validation of the Mini Nutritional Assessment Short-Form (MNA®-SF): A practical tool for identification of nutritional status. J Nutr Health Aging. 2009;13:782-788.

Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005; 112(17):2735–2752.

Feldman EL, Callaghan BC, et al. Diabetic neuropathy. Nat Rev Dis Primers. 2019;5(1): 41.

Ding X, Fang C, Li X, et al. Type 1 diabetes-associated cognitive impairment and diabetic peripheral neuropathy in Chinese adults: results from a prospective cross-sectional study. BMC Endocr Disord. 2019; 19(1):34.

Arnold SE, Arvanitakis Z, Macauley-Rambach SL, et al. Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums. Nat Rev Neurol. 2018; 14(3):168–181.

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Published

2025-05-25

How to Cite

LAZASHVILI, T., KAPETIVADZE, V., SILAGADZE, T., MAGLAPHERIDZE, Z., & KAPETIVADZE, I. (2025). DEMENTIA SEVERITY ASSESSED BY MINI MENTAL STATE EXAMINATION AND ITS METABOLIC CORRELATES. Experimental and Clinical Medicine Georgia, (2), 66–74. https://doi.org/10.52340/jecm.2025.02.12

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