FORMULATION, TECHNOLOGY AND BIOLOGICAL EVALUATION OF A BIPHASIC GEL  FOR WOUND HEALING

GIORGI BAKURIDZE; LASHA BAKURIDZE; KAKHI BAKURIDZE; DALI BERASHVILI; ALIOSHA BAKURIDZE

doi:10.52340/jecm.2024.04.28

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2026-01-29

FORMULATION, TECHNOLOGY AND BIOLOGICAL EVALUATION OF A BIPHASIC GEL FOR WOUND HEALING

Authors

GIORGI BAKURIDZE Tbilisi State Medical University
LASHA BAKURIDZE Tbilisi State Medical University
KAKHI BAKURIDZE Tbilisi State Medical University
DALI BERASHVILI Tbilisi State Medical University
ALIOSHA BAKURIDZE Tbilisi State Medical University

DOI:

https://doi.org/10.52340/jecm.2024.04.28

Keywords:

Formulation, Technology, and Biological Evaluation, Biphasic Gel, Wound Healing

Abstract

Disruption of the integrity of human skin, leading to wounds, poses a significant threat to the human body. Wound healing is crucial for achieving both functional and cosmetic outcomes. The healing process largely depends on various internal and external factors, including the form of medication used. Currently, biphasic gel (bigels) are considered promising drug formulations due to their ability to penetrate the skin effectively. Therefore, they are often used for both local and transdermal drug delivery. Based on conducted biopharmaceutical studies, the formulation for a wound-healing biphasic gel has been determined, consisting of the following components: silver sulfadiazine - 1.0%; isopropyl miristate - 7.0%; cedar oil – 17.0%; camphor - 1.0%; eucalyptus essential oil - 0.5%; soy lecithin - 1.5%; polysorbate 80 - 5.0%; methylcellulose - 2.5%; beta-cyclodextrin - 1.0%; lidocaine hydrochloride - 1.0%; Centella asiatica extract - 1.0%; aloe vera extract - 0.75%; aminocaproic acid - 1.5%; polyethylene glycol 400 - 8.0%; propylene glycol - 9.0%; sodium benzoate - 0.25%; distilled water - 42.0%. In this gel, the ratio of organogel to hydrogel is 25:75.

The technology for preparing the biphasic gel for wound healing has been developed, and a technological scheme has been proposed. This biphasic gel demonstrates a wide spectrum of significant antibacterial activity. Furthermore, the quality indicators of the proposed biphasic wound-healing gel meet the general requirements for gels.

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References

Gwak JH, Sohn SY. Identifying the trends in wound-healing patents for successful investment strategies. PLoS One; 2017 Mar 17;12(3): e0174203. https://doi.org/10.1371/journal.pone.0174203.

Marjana Tomic‐Canic, Jamie L. Burgess, Katelyn E. O’Neill, Natasa Strbo, Irena Pastar. Skin Microbiota and its Interplay with Wound Healing. American Journal of Clinical Dermatology. 2020; 21(1):S36–S43. https://doi.org/10.1007/s40257-020-00536-w

Erika Maria Tottoli, Rossella Dorati, Ida Genta, Enrica Chiesa, Silvia Pisani and Bice Conti. Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration. Pharmaceutics 2020, 12:735. doi:10.3390/pharmaceutics12080735.

Ibrahim, M.M.; Hafeza, S.A.; Mahdy, M.M. Organogels, hydrogels and bigels as transdermal delivery systems for diltiazem hydrochloride. AJPS 2013, 8:48–57.

Lupi, F.R.; Shakeel, A. et al. A rheological and microstructural characterization of bigels for cosmetic and pharmaceutical uses. Mater. Sci. Eng. 2016, 69:358–365.

Shakeel, A.; Farooq, U.; Gabriele, D.; Marangoni, A.G.; Lupi, F.R. Bigels and multi-component organogels: An overview from rheological perspective. Food Hydrocoll. 2021, 111:106190.

Rehman, K.; Zulfakar, M.H. Recent advances in gel technologies for topical and transdermal drug delivery. Drug. Dev. Ind. Pharm. 2014, 40:433–440.

Shakeel, A.; Lupi, F.R.; Gabriele, D.; Baldino, N.; De Cindio, B. Bigels: A unique class of materials for drug delivery applications. Soft Mater. 2018, 16:77–93.

Andonova, V.Y., Peneva, P.T. et al. Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels. TJPR 2017;16:1455-63.

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Published

2024-09-07

How to Cite

BAKURIDZE, G., BAKURIDZE, L., BAKURIDZE, K., BERASHVILI, D., & BAKURIDZE, A. (2024). FORMULATION, TECHNOLOGY AND BIOLOGICAL EVALUATION OF A BIPHASIC GEL FOR WOUND HEALING. Experimental and Clinical Medicine Georgia, (4), 98–102. https://doi.org/10.52340/jecm.2024.04.28

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FORMULATION, TECHNOLOGY AND BIOLOGICAL EVALUATION OF A BIPHASIC GEL FOR WOUND HEALING

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