THE IMPACT OF GENETIC THROMBOPHILIA ON OBSTETRIC COMPLICATIONS AMONG GEORGIAN POPULATION

THE IMPACT OF GENETIC THROMBOPHILIA ON OBSTETRIC COMPLICATIONS AMONG GEORGIAN POPULATION

Authors

  • DAREJAN KAPANADZE
  • NIKOLOZ KINTRAIA
  • TAMAR GOGIA

DOI:

https://doi.org/10.52340/jecm.2023.05.01

Keywords:

genetic thrombophilia, obstetric complications, Georgian population

Abstract

During the research, 160 women were examined with the obstetrics complications. The following parameters were evaluated to determine genetic thrombophilia: Leiden and prothrombin mutation (heterozygous and homozygous); homozygous mutation of plasminogen activator inhibitor (PAI-1); deficiency protein C, protein S and antithrombin III. There were 82 (51.3%) patients (group I) who had thrombophilic disorders, 78 (48.7%), who made up group II, did not have any form of thrombophilic disorders. There was no statistically significant difference between women with a history of stillbirth and preeclampsia. Preterm birth was observed in 20 (24,4%) women in group I and in 7 (8,8%) women in group II. The difference is statistically significant, OR 3,27. The women with a history of thrombosis complications during pregnancy and postpartum period were 14 (17,1%) among group I, and 4 (5,1%) - group II. The difference is statistically significant, OR 3,8. According to our data, the women with a history of preterm birth and thrombosis complications during pregnancy and postpartum period should be screened for the diagnosis of genetic thrombophilia.

Downloads

Download data is not yet available.

References

Louise E. Simcox, Laura Ormesher, Clare Tower and Ian A. Greer. Thrombophilia and Pregnancy Complications. Int J Mol Sci. 2015 Dec; 16(12): 28418-28428.

Dautaj A, Krasi G, Bushati V, Precone V, Gheza M, Fioretti F, Sartori M, Costantini A, Benedetti S, Bertelli M. Hereditary thrombophilia. Published online 2019 Sep 30. doi: 10.23750/abm.v90i10-S.8758

Croles FN, Nasserinejad K, Duvekot JJ, Kruip MJ, Meijer K, Leebeek FW. Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis. 2017 Oct 26; 359: j4452. doi: 10.1136/bmj.j4452.

Rodger MA, Carrier M, le Gal G, Martinelli I, Perna A, Rey E, de Vries JI, Gris JC. Low-Molecular-Weight Heparin for Placenta-Mediated Pregnancy Complications Study Group. Meta-analysis of low-molecular-weight heparin to prevent recurrent placenta-mediated pregnancy complications. Blood 2014; 123(6):822-8.

Greer IA, Brenner B, Gris JC. Antithrombotic treatment for pregnancy complications: Which path for the journey to precision medicine? Br. J. Haematol. 2014; 165:585–599.

Rodger MA, Betancourt MT, Clark P, Lindqvist PG, Dizon-Townson D, Said J, Seligsohn U, Carrier M, Salomon O, Greer IA. The association of factor V Leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: A systematic review and meta-analysis of prospective cohort studies. PLoS Med. 2010, 7: e1000292.

Kramer MS, Kahn SR, Rozen R, Evans R, Platt RW, Chen MF, Goulet L, Se´Guin L, Dassa C, Lydon J, McNamara H, Dahhou M, Genest J. Vasculopathic and thrombophilic risk factors for spontaneous preterm birth. International Journal of Epidemiology 2009; 38:715-723. doi:10.1093/ije/dyp167

Naeye RL. Pregnancy hypertension, placental evidences of low uteroplacental blood flow, and spontaneous premature delivery. Hum Pathol. 1989; 20:441-44.

Salafia CM, Vogel CA, Vintzileos AM, Bantham KF, Pezzullo J, Silberman L. Placental pathological findings in preterm birth. Am J Obstet Gynecol. 1991; 165:934-38.

Arias F, Rodriquez L, Rayne SC, Kraus FT. Maternal placental vasculopathy and infection: two distinct subgroups among patients with preterm labor and preterm ruptured membranes. Am J Obstet Gynecol. 1993; 168: 585-91.

Chaiworapongsa T, Espinoza J, Yoshimatsu J et al. Activation of coagulation system in preterm labor and preterm premature rupture of membranes. J Matern Fetal Neonate Med. 2002; 2002:368-73.

Gibson CS, MacLennan AH, Janssen NG et al. Associations between fetal inherited thrombophilia and adverse pregnancy outcomes. Am J Obstet Gynecol 2006; 194: 947.e1-10.

Erhardt E, Stankovics J, Molnar D, Adamovich K, Melegh B. High prevalence of factor V Leiden mutation in mothers of premature neonates. Biol Neonate 2000; 78:145-46.

Gopel W, Kim D, Gortner L. Prothrombotic mutations as a risk factor for preterm birth. Lancet 1999; 353:1411-12.

Werner EF, Lockwood CJ. Thrombophilias and Stillbirth. Clin Obstet Gynecol. Sep 2010; 53(3):617-627. doi: 10.1097/GRF.0b013e3181eb658c.

Downloads

Published

2023-10-12

How to Cite

KAPANADZE, D., KINTRAIA, N., & GOGIA, T. (2023). THE IMPACT OF GENETIC THROMBOPHILIA ON OBSTETRIC COMPLICATIONS AMONG GEORGIAN POPULATION . Experimental and Clinical Medicine Georgia, (5), 10–15. https://doi.org/10.52340/jecm.2023.05.01

Issue

Section

Articles

Most read articles by the same author(s)

Similar Articles

<< < 1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.

Loading...