NEW SARS-COV-2 INFECTION, PREGNANCY AND HYPERBILIRUBINEMIA OF NEWBORNS

NEW SARS-COV-2 INFECTION, PREGNANCY AND HYPERBILIRUBINEMIA OF NEWBORNS

Authors

  • NINO KHOTIVARI
  • ELISO TURKADZE

DOI:

https://doi.org/10.52340/jecm.2023.05.16

Keywords:

COVID-19, SARS-CoV-2, NICU, hyperbilirubinemia

Abstract

On the basis of Department of Perinatology of Tbilisi State Medical University First University Clinic, within a framework of retrospective, cohort, targeted study, the medical histories of 23 pregnant women (infected with Sars-CoV-2 at different stages of pregnancy and childbirth) and their newborns were studied in 2022. These 23 newborns were transferred in the Neonatal Intensive Care Unit (NICU), due to hyperbilirubinemia, for the purpose of phototherapy and further monitoring of bilirubin level. As it was determined by data analysis, in 17 out of 23 cases, SARS-CoV-2 infection during pregnancy and childbirth were characterized by a moderate or severe duration of infection, and their newborns were diagnosed with hyperbilirubinemia with an unspecified cause, the main risk-factors of hyperbilirubinemia were excluded. Based on our study, it can be assumed that hyperbilirubinemia is a neonatal consequence of SARS-CoV-2, probably cause placental vascular malperfusion and polycythemia in fetuses, which may be a compensatory response to this infection.

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References

Huang C,Wang Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; (published online Jan 24. https://doi.org/10.1016/S0140-6736(20)30183-5.)

Ronald J Wong, BA, Vinod K Bhutani, MD, FAAP, Unconjugated hyperbilirubinemia in neonates: Risk factors, clinical manifestations, and neurologic complications

Bhutani VK, Johnson L, Sivieri EM., Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics. 1999; 103:6-14. doi: 10.1542/peds.103.1.6.

Rebutini PZ, Zanchettin AC, et. al. Association Between COVID-19 Pregnant Women Symptoms Severity and Placental Morphologic Features. Front Immunol. 2021 May 26;12:685919. doi: 10.3389/fimmu.2021.685919. eCollection 2021.PMID: 34122449

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Published

2023-10-12

How to Cite

KHOTIVARI, N., & TURKADZE, E. (2023). NEW SARS-COV-2 INFECTION, PREGNANCY AND HYPERBILIRUBINEMIA OF NEWBORNS. Experimental and Clinical Medicine Georgia, (5). https://doi.org/10.52340/jecm.2023.05.16

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