Covid-19, immunotherapy, prospects


COVID-19 pandemic is a real threat for the people worldwide. Currently there is no specific treatment to eliminate SARS-CoV2 from the infected humans. In this review we describe and analyze several therapeutical preparations, which target immune system, used in the clinical trials to treat COVID-19. We discuss immune system modulation in two main aspects: first, achievement of passive immunity as prophylactic of severe and critical disease in SARS-CoV-2 infected people with concomitant risks; and, second, inhibition of cytokine storm, which is main cause of severe and critical disease. Finally, according to the USA NIH guidelines, monoclonal antibodies for passive immunity and dexamethasone for cytokine storm are discussed with emphasis on the timing of administration concerning COVID-19 patients’ stage of disease.


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