Vitamin D, neurological syndromes, development


Over the past decade, many reports addressed the importance of vitamin D in the development of neurological, neurodegenerative and mental diseases. Nevertheless, there are many controversial and unresolved problems, contradictory opinions and data. The aim of the study was to determine the importance of vitamin D deficiency in the development and course of some neurological syndromes in children and adolescents. 150 patients aged 1 to 16 years were studied. According to the clinic, they were divided into following groups: A - mild mental and speech delay (17 patients); В - behavioral disorder (18); B1 - autistic spectrum disorder (13); C - Attention Deficit Hyperactivity Disorder (17); D - frequent headache (24); E - fatigue (19); F - insomnia (23); G - seizures (19). The research resulted in a couple of conclusions: 40% of patients with attention deficit hyperactivity disorder had got significantly lower levels of Vitamin D in each age group. Administering vitamin D (Aquadetrim) during 2.5 months reduced hyperactivity, aggression, improved memory and speech skills. 38% of patients with epilepsy who had been taking antiepileptic drugs for more than 3 years had low levels of vitamin D in their blood (11.4 to 16.5 ng / ml). However, prescribing high doses of vitamin D in combination with anticonvulsants might develop side effects, which makes it necessary to control vitamin D level during treatment. Low levels of vitamin D (13,4-18.8 ng / ml) were found in 28% of practically healthy children aged 6 to 16 years (control group). A detailed study of the anamnesis revealed frequent fatigue, periodic headaches, insomnia. Vitamin D deficiency has an important role in the pathogenesis of somatic and as well as neurological diseases, and its deficiency is difficult to diagnose due to polysymptomatic clinical manifestations, we consider it necessary to include vitamin D research in a routine (mandatory) analysis to determine its role in both acute and chronic diseases.


Download data is not yet available.


Alharbi FM. Update in vitamin D and multiple sclerosis. Neurosciences (Riyadh). 2015 Oct; 20(4): 329–335.doi: 10.17712/nsj.2015.4.20150357

Atapattu N, Shaw N, Högler W. Relationship between serum 25-hydroxyvitamin D and parathyroid hormone in the search for a biochemical definition of vitamin D deficiency in children. Pediatric Research volume 74, 02 September 2013, pages552–556 (2013).

Bivona G, Gambino CM, Iacolino G, Ciaccio M. Vitamin D and the nervous system. Neurol Res. 2019 Sep;41(9):827-835. doi: 10.1080/01616412.2019.1622872. Epub 2019 May 30.

Cannell JJ, Grant WB. What is the role of vitamin D in autism? Dermatoendocrinol. 2013 Jan 1;5(1):199-204. doi: 10.4161/derm.24356.

Cesur Y, Yuca SA, Kaya A, Yilmaz C, Bay A. Vitamin D deficiency rickets in infants presenting with hypocalcaemic convulsions. West Indian Med J 2013 Mar;62(3):201-4

Del Campo N, Chamberlain SR, Sahakian, Robbinsb TW. The Roles of Dopamine and Noradrenaline in the Pathophysiology and Treatment of Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 15 June 2011, Pages e145-e157.

Dörr J, Ohlraun S, Skarabis H, Paul F. Efficacy of Vitamin D Supplementation in Multiple Sclerosis (EVIDIMS Trial): study protocol for a randomized controlled trial. Trials 2012. 13: 15.

Eyles D, ThomasBurne T, McGrathabc J. Vitamin D in fetal brain development. Seminars in Cell & Developmental Biology. August 2011, Pages 629-636.

Eyles DW, Burne TH, McGrathab JJ. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Frontiers in Neuroendocrinology.Volume 34, Issue 1, January 2013, Pages 47-64.

Gardener H, Spiegelman D, Buka SL. Prenatal risk factors for autism: comprehensive meta-analysis. Br J Psychiatry. 2009 Jul;195(1):7-14. doi: 10.1192/bjp.bp.108.051672.

Garipardic M, Doğan M, Bala KA, Mutluer T, Kaba S, Aslan O. Association of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders with Mean Platelet Volume and Vitamin D. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 20 Mar 2017, 23:1378-1384

Goksugur SB, Tufan AT, Semiz M, Vitamin D status in children with attention-deficit–hyperactivity disorder. Pediatric int, 2014;56:515-19.

Häusler D, Torke S, Peelen E, Bertsch Th, Djukic M, Roland Nau, Larochelle C, Zamvil SS, Brück W, and Martin MS. High dose vitamin D exacerbates central nervous system autoimmunity by raising T-cell excitatory calcium. Brain. 2019 Sep; 142(9): 2737–2755. Published online 2019 Jul 13. doi: 10.1093/brain/awz190ю

Holton FH, Johnstone JM, Brandley ET, Nigg JT. Evaluation of dietary intake in children and college students with and without attention-deficit/hyperactivity disorder. Nutr Neurosci. 2019 Sep;22(9):664-677. doi: 10.1080/1028415X.2018.1427661. Epub 2018 Jan 23.

Hosseinpour F, Ellfolk M, Norlin M, Wikvall K. Phenobarbital suppresses vitamin D3 25-hydroxylase expression: a potential new mechanism for drug-induced osteomalacia. Biochem Biophys Res Commun. 2007 Jun 8;357(3):603-7. doi: 10.1016/j.bbrc.2007.03.177. Epub 2007 Apr 9.

Huisman-van Dijk HM, Schoot Rv, Marleen M. Rijkeboer MM et al: The relationship between tics, OC, ADHD and autism symptoms: A cross- disorder symptom analysis in Gilles de la Tourette syndrome patients and family-members. Phychiatry Res, 2016; 237:138-46.

Jellen LC, Lu L, Wang X,at al. Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice. Neuroscience.Volume 252, 12 November 2013.

Kassi E, Adamopoulos Ch, Basdra EB, Papavassiliou AG. Role of Vitamin D in Atherosclerosis. Circulation. 2013;128:2517–2531

King BJ, Molly BD et al. Generalizability and reproducibility of functional connectivity in autism. Mol Autism. 2019 Jun 24;10:27. doi: 10.1186/s13229-019-0273-5. eCollection 2019

Laursen JH, Søndergaard HB, Albrechtsen A, et al: Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis. Mult Scler. 2015 Oct;21(11):1414-22. doi: 10.1177/1352458514563590. Epub 2014 Dec 22

Min-Jing Lee, Miao-Chun Chou, Wen-Jiun Chou, Chien-Wei Huang, Ho-Chang Kuo, Sheng-Yu Lee, Liang-Jen Wang. Heavy Metals' Effect on Susceptibility to Attention-Deficit/Hyperactivity Disorder: Implication of Lead, Cadmium, and Antimony. Int J Environ Res Public Health. 2018 Jun 10;15(6):1221. doi: 10.3390/ijerph15061221.

Morales E, Julvez J, Torrent M, atal. Vitamin D in Pregnancy and Attention Deficit Hyperactivity Disorder-like Symptoms in Childhood. Epidemiology.2015 Jul;26(4):458-65. doi: 10.1097/EDE.0000000000000292.

Mossin MH, Aaby JB, Christine Dalgård Inverse associations between cord vitamin D and attention deficit hyperactivity disorder symptoms: A child cohort study. Australian & New Zealand Journal of Psychiatry. 10.1177/0004867416670013, 2016

Murdaca G, Tonacci A, Negrini S, etal. Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications. Autoimmun Rev. 2019 Sep;18(9):102350. doi: 10.1016/j.autrev.2019.102350. Epub 2019 Jul 16.

Nielsen NM, Munger KL, Koch-Henriksen N, M Hougaard DM, at al. Neonatal vitamin D status and risk of multiple sclerosis: A population-based case-control study. Neurology.2017 Jan 3;88(1):44-51. doi: 10.1212/WNL.3454. Epub 2016 Nov 30.

Patrick RP, Ames BN. Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior. FASEB J. 2015 Jun;29(6):2207-22. doi: 10.1096/fj.14-268342. Epub 2015 Feb 24.

Patrick RP, Ames BN. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J. 2014 Jun;28(6):2398-413. doi: 10.1096/fj.13-246546. Epub 2014 Feb 20.

Pietras SM, Obayan BK, Cai MH, Michael F Holick. Vitamin D2 treatment for vitamin D deficiency and insufficiency for up to 6 years. Archives of Internal Medicine, 01 Oct 2009, 169(19):1806-1808 DOI: 10.1001/archinternmed.2009.361 PMID: 19858440

Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, Shoenfeld Y, Lerchbaum E, Llewellyn DL, Kienreich K, Soni M. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev.2013 Aug;12(10):976-89. doi: 10.1016/j.autrev.2013.02.004. Epub 2013 Mar 28.

Principi N, Bianchini S, Baggi E, Esposito S. Implications of maternal vitamin D deficiency for the fetus, the neonate and the young infant. Eur J Nutr. 2013 Apr;52(3):859-67. doi: 10.1007/s00394-012-0476-4. Epub 2012 Dec 9.

Simpson S Jr, Blizzard L, Otahal P, Ingrid Van der Mei, Bruce Taylor etal: Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis. J Neurol Neurosurg Psychiatry. 2011 Oct;82(10):1132-41. doi: 10.1136/jnnp.2011.240432. Epub 2011 Apr 8.

Spedding S. Vitamin D and Depression: A Systematic Review and Meta-Analysis Comparing Studies with and without Biological Flaws. Nutrients. 2014 Apr; 6(4): 1501–1518.Published online 2014 Apr 11. doi: 10.3390/nu6041501

Sucksdorff M, Brown AS, Chudal R, Surcel H-M, Hinkka-Yli-Salomäki S, Cheslack-Postava K, Gyllenberg D, Sourander A. Maternal Vitamin D Levels and the Risk of Offspring Attention-Deficit/Hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry. 2021 Jan;60(1):142-151.e2. doi: 10.1016/j.jaac.2019.11.021. Epub 2019 Dec 19.

Thorne-Lyman Al, Fawzi WW. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Paediatr Perinat Epidemiol. 2012 Jul;26 Suppl 1(0 1):75-90. doi: 10.1111/j.1365-3016.2012.01283.x

Vogiatzi MG, Jacobson-Dickman E, DeBoer MD, Drugs, and Therapeutics Committee of The Pediatric Endocrine Society. Vitamin D supplementation and risk of toxicity in pediatrics: a review of current literature. J Clin Endocrinol Metab. 2014 Apr;99(4):1132-41. doi: 10.1210/jc.2013-3655. Epub 2014 Jan 23

Zhang et al.-Effect of antiepileptic drags on bone mineral density and bone metabolism in children: a meta-analisis. J.Zhejiang Univ.Sci.B-2015,vol.16.N7.p611-621.

Асланян В.П. Диагностика соотношения вербального и невербального компонентов в умственном развитии младшего школьника. Автор.дисс.канд.психол.наук,1996.

Байрашева В.К. Дефицит витамина Д – симптомы и лечение .2021. Педиатр.96с.

Верещагина О.А.Залетина А.В. и др. Влияние уровня витамина Д в перинатальном периоде на состояние здоровья. Журн.Ортопедия,травмат, и восстановит.хирургия детского возраста. 2015.т.3,(4),62-66.

Галашевская А.А., Почкайло А.С.—Состояние фосфорно-кальциевого обмена и обеспеченности витамина Д у детей на фоне длительного лечения антиконвульсантами.Журн.Белор.мед.академии. 2019, стр. 21 -25, Минск.

Захарова И.М.,Мальцев С.В. Результаты многоцентрового исследования «Родничок» по изучению недостаточности витамина Д у детей раннего возраста. Вопросы современной педиатрии.2014г.13(6),122-126.

Захарова И.Н, Боровик Т.Э. и др. Витамин Д – Новый взгляд на роль в организме. Учебное пособие. М .ГБОУ ДПО РМАПО .2014г. 104 с.

Лашкова Ю.С. Профилактика и лечение дефицита витамина Д –современный взгляд на проблему. Педиатрическая фармакология. 2015,12(1),46-51.

Мальцев С.В., Архипова Н.Н.,Шакирова Э.М. Витамин Д, кальций и фосфаты у здоровых детей и при патологии. 2012, Казань,120 с.

Манелис Н.Т. - Развитие представления о ментальных состояниях в онтогенез. Школа здоровья, 2014 г.№4 59-74.

Пигарова Е.А., Бородич Т.С. и др. Пилотное исследование эффективности и безопасности применения высокой пероральной дозы колекальциферола в коррекции дифицита витамина Д. Материалы второго Всероссийского конгресса «Иновационные технологии в эндокринологии» 25-28 марта,2014г.Москва.

Союз педиатров России Национальная программа «Недостаточность витамина Д у детей и подростков РФ». Современные подходы к коррекции. М. Педиатр.2018.96с.

Студеникин В.М. с соавт. Альтернативные и дополнительные методы фармакотерапии эпилепсиию РАМН «Эффективная фармакотерапия», Педиатрия, № 2,2011, стр.22-25.

Студеникин В.М., Казакова К.А., Акоева Ю.С., Мигали А.В. Рахит, недостаточность витамина Д и Всемирный Консенсус по профилактике и лечению нутритивного рахита. Взгляд Российских педиатров. 2016 г. Росс.педиатрич.журн.2016г.

Шнейдер Н.А. – Влияние антиконвульсантов на костную ткань. Междун.неврол.журнал 6 (10) 2006




How to Cite





Most read articles by the same author(s)

Similar Articles

<< < 4 5 6 7 8 9 10 11 12 13 > >> 

You may also start an advanced similarity search for this article.