როგორ უნდა ციტირება
გონგაძე ნ., გაბუნია ლ., გვიშიანი მ., მახარაძე თ., & მირზიაშვილი მ. (2018). ენდოთელინი-1-ის როლი არტერიული ჰიპერტენზიის დროს. თბილისის სახელმწიფო სამედიცინო უნივერსიტეტის სამეცნიერო შრომათა კრებული, 51, 36–38. Retrieved from https://journals.4science.ge/index.php/CSW/article/view/87
ანოტაცია
მრავალი კვლევით ნაჩვენებია ენდოთელინი-1-ის (E-1) მონაწილეობა სისხლძარღვთა ტონუსის რეგულაციაში. გამოვლენილია, რომ ენდოთელიუმის ფუნქციის დარღვევას შეიძლება ადგილი ჰქონდეს ბაზალური სიმპათიკური/პარასიმპათიკური ტონუსის ცვლილებამდე. ექსპერიმენტული კვლევებით რეგისტრირებულ იქნა სისხლძარღვთა კედელში E-1 ჭარბი ექსპრესია ვირთაგვების არტერიული ჰიპერტენზიის ისეთ მოდელებში, როგორიცაა: დეოქსიკორტიკოსტერონ/ აცეტატით (DOCA) ინდუცირებული ჰიპერტენზია, ინსულტისადმი მიდრეკილების მქონე სპონტანურ-ჰიპერტენზირებული ვირთაგვების (SHR), ანგიოტენზინი II-ის (Ag-II) ინფუზიით გამოწვეული და ცალი თირკმელი 1 კლიპით (1K-1C) მოდელირებული გოლდბლატის ჰიპერტენზიის მქონე ცხოველები, მაშინ როდესაც SHR-ში, 2-თირკმელი- 1-კლიპი და L-ნიტრო-არგინ-მეთილსტერინი (L-NAME) გამოწვეული ჰიპერტენზიის დროს E-1-ის ჭარბი ექსპრესია არ იყო გამოხატული. დადგენილ იქნა, რომ ვასკულური E-1-ის პროდუქციის აქტივაცია ასოცირდება რეზისტიული არტერიების ჰიპერტროფული რემოდელირებასთან და ვაზოპრესინის (V) გამოთავისუფლებასთან, ვინაიდან EA და V1 რეცეპტორების ანტაგონისტები DOCA-მარილოვანი ჰიპერტენზიის დროს ამცირებდნენ სისხლძარღვებში პრეპრო E-1-ის გენის გაძლიერებულ ექსპრესიას და აქვეითებდნენ სისხლის არტერიულ წნევას. რაც შეეხება 2K-1C, SHR და L-NAME-თი ჰიპერტენზიის მქონე ცხოველებს, დადასტურებულ იქნა E-1-ის უმნიშვნელო როლი ამ ტიპის ჰიპერტენზიის ფორმირებაში.
წყაროები
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7. Yanagisava M, Kurihare H, Kimura S. et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988. 332:441-415.
8. Pemow J., Franco-Cerecedo A, Matran R. et al. Effect of endothelin-1 on regional vascular resistance in the pig. J. Cardiovasc. Pharmacol. 1989, 13(Suppl. 5): S205-S206.
9. Schichiri M, Hirata Y, Ando K: Plasma endothelin levels in hypertension and chronic renal failure. Hypertension. 1990.15: 493-496.
10. Schiffrin E.L. Role of Endothelin-1 in Hypertension. 1999. 34:876-881.
11. Li J.S., Schiffrin E.L. Effect of chronic treatment of adult SHR with an endothelin receptor antagonist. Hypertension. 1995.25(part I): 495-500.
12. Cargnelli G, Rossi G, Bova S. et al, In vitro vascular reactivity to endothelin: a comparison between young and old normotensive and hypertensive rats. Clin. Exp. Hypertension A. 1990. 12:1437-1451.
13. Schiffrin E. L., Lariviere R, Li J.S. et al. Deoxycorticosterone acetate plus salt induces overexpression of vascular endothelin-1 and severe vascular hypertrophy in SHR. Hypertension. 1995. 25(2): 769-773.
14. Li J, S, Schurch W, Schiffrin E. Renal and vascular effect of chronic endothelin receptor antagonism in malignant hypertensive rats. Am. J. Hypertens. 1996. 9: 803-811.
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16. Sventek P, Turgeon a, Garcia R, Schiffrin E. L. Vascular and cardiac overexpression of endothelin-1 gene in onekidney one clip Goldblatt hypertensive rats but only in the late phase of two-kidney one clip Goldblatt hypertension. J. Hypertension. 1996. 14:57-64.
17. Hocher B, George I, Rebstock J. et al. Endothelin system- dependent cardiac remodeling in renovascular hypertension. Hypertension. 1999. 33:816-622.
18. Schiffrin E. L., Thibault G. Plasma endothelin in human essential hypertension. Am. J. Hypertens. 1991.4:303-308.
19. Erguli S, Parish D. C, Puett D. et al. Racial differences in plasma E1 concentrations in individuals with essential hypertension. Hypertension. 1996. 28:652-655.
20. Noll G, Wenzel R.B, Schneider M. et al. Increased activation of sympathetic nervous system and endothelin by mental stress in normotensive offspring of hypertensive parents. Circulation. 1996. 93:866-869.
21. Dhaun N, Moorhouse R, Iain M. et al. Diurnal variation in blood pressure and arterial stiffness in chronic kidney disease: The role of endothelin-1. Hypertension. 214. 64: 296-304.
22. Stow L. R, Richards J, Cheng K.Y. et al. The circadiab protein period 1 contributes to blood pressure control and coordinately regulates renal sodium transport genes. Hypertension. 2012. 59:1151-1156.
23. Parvanova A, Van de Meer I. M, Iliev I. et al. Effect on blood pressure of combine inhibition of endothelin-converting enzyme and neutral endopeptidase with daglutril in patients with type 2 diabetes who have albuminuria: a randomized crossover, double-blind, placebo-controlled trial. Lancet. Diabetes Endocrinol. 2013. 1:19-27.
24. Dhaun N, Melville V, Kramer W. et al. The pharmacokinetic profile of sitaxsentan, a selective endothelin receptor antagonist, in varying degrees of renal impairment. British J. Clin. Pharmacol. 2007. 64: 733-737.
25. Dhaun N, Macintyre I.M, Melville V. Effects of endothelin receptor antagonism relate to the degree of reninangiotensin system blockade in chronic proteinuric kidney disease. Hypertension. 2009. 54:e19-e20.
26. Uzu T, Kimura G. Diuretics shift circadian rhythm og blood pressure from nondipper to dipper in essential hypertension. Circulation. 1999. 100:1635-1638.
27. Dhaun N, Goddard J, Webb D. J. The endothelin system and its antagonism in chronic kidney disease. J. Am. Soc. Nephrol. 2006. 17:943-955.
28. Nikolaeva S, Pradervand S, Genteno G. et al. The circadian clock modulates renal sodium handling. J. Am. Soc. Nephrol. 2012. 23:1019-1026.
29. Bugaj V, Pochynyuk O, Mironova E. et al. Regulation of the epithelial Na+-channel by endothelin-1 in rat collecting duct. Am. J. Phys. Renal Physiol. 2008. 295:F1063- F1070.
30. Ahn D, Ge Y, Stricklett P. K. et al. Collecting ductspecific knockout of endothelin-1 causes hypertension and sodium retention. J. Clin. Invest. 2004.114:504-511.
31. Chen D.D, Dong Y. G. and Chen A.F. Endothelin-1 critically contribute to EPC reduction and dysfunction via ETA/NADPH oxidase pathway-induced oxidative stress in salt sensitive hypertension. Hypertension. 2012. 59(5): 1037- 1043.
32. Lemne C, Vesterqvist O, Egberg N.et al. Platelet activation of prostacyclin release in essential hypertension. Prostaglandines. 1992. 44:219-235.
2. Bonhomme M. C., Cantin M, Garsia R. Relaxing effect of atrial natriuretic factor on endothelin precontracted vascular strips. Proc. Soc. Exp. Biol. Med. 1989, 191:305- 315.
3 . Vanhoutte P. M. Endothelium and control of vascular function. Hypertension. 1989, 13: 658-667.
4. Lemne C.E., Lundberg T, Theodorsson T, Faire U.D. Increased basal concentrations of plasma endothelin in borderline hypertension. J. of Hypertension. 1994, 12:1069- 1074.
5. Schiffrin E.L., Thibault G: Plasma endothelin in human essential hypertension. Am. J. Hypertension. 1991.4: 303-308.
6. Kohno M, Yasunari K, Murakawa K. L. et al. Plasma Immunoreactive Endothelin in Essential Hypertension. Am. J. Med. 1990. 88:614-618.
7. Yanagisava M, Kurihare H, Kimura S. et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988. 332:441-415.
8. Pemow J., Franco-Cerecedo A, Matran R. et al. Effect of endothelin-1 on regional vascular resistance in the pig. J. Cardiovasc. Pharmacol. 1989, 13(Suppl. 5): S205-S206.
9. Schichiri M, Hirata Y, Ando K: Plasma endothelin levels in hypertension and chronic renal failure. Hypertension. 1990.15: 493-496.
10. Schiffrin E.L. Role of Endothelin-1 in Hypertension. 1999. 34:876-881.
11. Li J.S., Schiffrin E.L. Effect of chronic treatment of adult SHR with an endothelin receptor antagonist. Hypertension. 1995.25(part I): 495-500.
12. Cargnelli G, Rossi G, Bova S. et al, In vitro vascular reactivity to endothelin: a comparison between young and old normotensive and hypertensive rats. Clin. Exp. Hypertension A. 1990. 12:1437-1451.
13. Schiffrin E. L., Lariviere R, Li J.S. et al. Deoxycorticosterone acetate plus salt induces overexpression of vascular endothelin-1 and severe vascular hypertrophy in SHR. Hypertension. 1995. 25(2): 769-773.
14. Li J, S, Schurch W, Schiffrin E. Renal and vascular effect of chronic endothelin receptor antagonism in malignant hypertensive rats. Am. J. Hypertens. 1996. 9: 803-811.
15. Intengan H. D, He G, Schiffrin E.L. Effect of V1 vasopressin antagonism on small artery structure and vascular expression of preproendotellin-1 in DOCA-salt hypertensive rats. Hypertension. 1998. 32:770-777.
16. Sventek P, Turgeon a, Garcia R, Schiffrin E. L. Vascular and cardiac overexpression of endothelin-1 gene in onekidney one clip Goldblatt hypertensive rats but only in the late phase of two-kidney one clip Goldblatt hypertension. J. Hypertension. 1996. 14:57-64.
17. Hocher B, George I, Rebstock J. et al. Endothelin system- dependent cardiac remodeling in renovascular hypertension. Hypertension. 1999. 33:816-622.
18. Schiffrin E. L., Thibault G. Plasma endothelin in human essential hypertension. Am. J. Hypertens. 1991.4:303-308.
19. Erguli S, Parish D. C, Puett D. et al. Racial differences in plasma E1 concentrations in individuals with essential hypertension. Hypertension. 1996. 28:652-655.
20. Noll G, Wenzel R.B, Schneider M. et al. Increased activation of sympathetic nervous system and endothelin by mental stress in normotensive offspring of hypertensive parents. Circulation. 1996. 93:866-869.
21. Dhaun N, Moorhouse R, Iain M. et al. Diurnal variation in blood pressure and arterial stiffness in chronic kidney disease: The role of endothelin-1. Hypertension. 214. 64: 296-304.
22. Stow L. R, Richards J, Cheng K.Y. et al. The circadiab protein period 1 contributes to blood pressure control and coordinately regulates renal sodium transport genes. Hypertension. 2012. 59:1151-1156.
23. Parvanova A, Van de Meer I. M, Iliev I. et al. Effect on blood pressure of combine inhibition of endothelin-converting enzyme and neutral endopeptidase with daglutril in patients with type 2 diabetes who have albuminuria: a randomized crossover, double-blind, placebo-controlled trial. Lancet. Diabetes Endocrinol. 2013. 1:19-27.
24. Dhaun N, Melville V, Kramer W. et al. The pharmacokinetic profile of sitaxsentan, a selective endothelin receptor antagonist, in varying degrees of renal impairment. British J. Clin. Pharmacol. 2007. 64: 733-737.
25. Dhaun N, Macintyre I.M, Melville V. Effects of endothelin receptor antagonism relate to the degree of reninangiotensin system blockade in chronic proteinuric kidney disease. Hypertension. 2009. 54:e19-e20.
26. Uzu T, Kimura G. Diuretics shift circadian rhythm og blood pressure from nondipper to dipper in essential hypertension. Circulation. 1999. 100:1635-1638.
27. Dhaun N, Goddard J, Webb D. J. The endothelin system and its antagonism in chronic kidney disease. J. Am. Soc. Nephrol. 2006. 17:943-955.
28. Nikolaeva S, Pradervand S, Genteno G. et al. The circadian clock modulates renal sodium handling. J. Am. Soc. Nephrol. 2012. 23:1019-1026.
29. Bugaj V, Pochynyuk O, Mironova E. et al. Regulation of the epithelial Na+-channel by endothelin-1 in rat collecting duct. Am. J. Phys. Renal Physiol. 2008. 295:F1063- F1070.
30. Ahn D, Ge Y, Stricklett P. K. et al. Collecting ductspecific knockout of endothelin-1 causes hypertension and sodium retention. J. Clin. Invest. 2004.114:504-511.
31. Chen D.D, Dong Y. G. and Chen A.F. Endothelin-1 critically contribute to EPC reduction and dysfunction via ETA/NADPH oxidase pathway-induced oxidative stress in salt sensitive hypertension. Hypertension. 2012. 59(5): 1037- 1043.
32. Lemne C, Vesterqvist O, Egberg N.et al. Platelet activation of prostacyclin release in essential hypertension. Prostaglandines. 1992. 44:219-235.
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