STEROID INDUCED COMPLICATIONS IN SURGICAL PATIENTS
PDF

How to Cite

Goletiani, M., Tomadze, G., Megreladze, A., Azmaiparashvili, G., & Imnadze, N. (2018). STEROID INDUCED COMPLICATIONS IN SURGICAL PATIENTS. Collection of Scientific Works of Tbilisi State Medical University, 51, 34–36. Retrieved from https://journals.4science.ge/index.php/CSW/article/view/86

Abstract

Presented article is devoted to surgical complications in steroid treated patients after emergency abdominal surgery. We analyzed 6 patients who underwent emergency abdominal surgery where postoperative period was complicated with either stress ulcer perforation of stomach, duodenum and small intestine or upper GI bleeding. Four patients were male, two – female, with age range 42-76. The reasons of steroid therapy were arthritis, bronchial asthma. One patient was operated due to secum cancer: operation performed – right sided colectomy with ileotransversoanastomosis. One patient was operated due to sigmoid bowel diverticulitis: operation performed – sigmoid resection with transverso-sigmoanastomosis. Three patients were operated due to destructive cholecystitis: operations performed – cholecystectomy and one patient was operated due to intestinal ileus: operation performed – sinechiolysis. Postoperative complications: perforation of acute duodenal ulcer (1 case), perforation of acute small intestine ulcer (3 cases), upper GI bleeding (2 cases). One patient died due to late relaparotomy (duodenal ulcer perforation). Four patients were treated with operation, two patients – conservatively. It was concluded that main manifestation of surgical complications of steroid treated patients are in GI tract. Main complications are severe ulcer perforation and bleeding from peptic ulcers. Steroids must be used carefully in combination with PPI.

PDF

References

1. Oishi Y, Fu ZW, Ohnuki Y, et al. Molecular basis of the alteration in skin collagen metabolism in response to in vivo dexamethasone treatment: effects on the synthesis of collagen type I and III, collagenase and tissue inhibitors of metalloproteinases. Br J Dermatol 2002; 147: 859 – 68
2. PPolat A, Nayci A, Polat G, et al. Dexamethasone down-regulates endothelial ewpression of intercellular adhesion molecule and impairs the healing of bowel anastomoses. Eur J surg 2002; 168: 500 – 6
3. Aberra FN, Lewis JD, Hass D, et al, Corticosteroids and immunomodulators: postoperative infectious complication risk in inflammatory bowel desease patients. Gastroenterology 2003; 125: 320 – 7
4. Wicke C, Halliday B, Allen D, et al. Effects of steroids and retinoids on wound healing. Arch Surg 2000; 135: 1265 -70
5. Audrey S. Wang, M. D., Ehrin J. Armstrong, M. D., April W. Armstrong, M. D. Corticosteroids and wound healing: clinical considerations in the perioperative period The American Journal of Surgery 2013; 206: 410 – 417
6. (пер. с Английского Грехем Л. Хил, Кристо¬фер Бамбач - В кн. : Гастроэнтерология 3, М. Медицина 1985 г. с. 134-148)
7. А. Я. Фишенко, С. И. Барило, В. М. Рыжановская Хирургические осложнения при кортикосте-роидной терапии, Хирургия 1980 г №11 с. 96-100)
8. Е. А. Жук, В. И. Полянский - В кн. : Актуа¬льные вопроси гастроэнтерологии. М 1972 г. вып. 5 с. 37-44
9. დ. წოტოიძე აკტჰ და კორტიკოიდების გამოყენება ზოგიერთი ქირურგიული დაავადების დროს. გ. “საბჭოთა საქართველო”. თბილისი 1975 წ. გვ. 17-26
10. Г. П. Макаренко, А. В. Богданов - В кн.: Сви¬щи желудочно кишечного тракта М. Медицина 1986 г. с. 46-61
11. Surgical menagement of complications of steroid therapy From the Department of Surgery University of Alabama Medical Center Birmingham, Alabama Arnold G. Diethelm. M. D. 1977. mar. 185 (3) pg 251 – 263
12. Bowel perforation in steroid-treated patients Stephen G. Remine M.D. Donald C. Mcilrath M.D. From the Mayo Clinic and Mayo Foundation Rochester, Minesota 1980 oct. 192 (4) pg 581- 586
13. Steroid Induced Sigmoid Diverticular Perforation in a patient with Temporal Arteritis B. Kaya, O. Aras, O. Bat Nuriye Esen Bulat kemal Meisoglu 2012 mar. doi: 10.4137/CPath. S7924

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...