Acanthosis nigricans as a marker of a malignant process in a patient with ovarian adenocarcinoma (Clinical case review)

Abstract

Acanthosis nigricans is a dematosis that is clinically characterized by the appearance of symmetrical, hyperpigmented, hyperkeratotic, papillomatous patches located on the neck, nape, axillary fossa, and large folds. 20-25% of cases of acanthosis nigricans are associated with malignant acanthosis nigricans. Paraneoplastic acanthosis nigricans is a marker of a malignant tumor developing in the body. 90% of cases are associated with intra-abdominal neoplasms. Rarely with tumors of the ovary, uterus, mammary gland, and lungs. Prompt identification of the aforementioned dermatosis enables timely implementation of an intricate array of therapeutic interventions.

Clinical case: patient L.D. 69 years old, with clinical manifestations of acanthosis nigricans and adenocarcinoma of the right ovary, and the degree of tumor differentiation - High Grade 3, Pt3aN1MX, Stage III B.