INFLUENCE OF POLYPHENOLS ON THE BIOAVAILABILITY OF STATINS

Authors

  • Bokuchava N.
  • Murtazashvili T.
  • Sivsivadze K.
  • Gongadze N.
  • Mitagvaria N.

Abstract

Cardio-vascular diseases (CVD) are considered as the main reason of mortality nowadays. One of its main provoking agents is hyperlipidemia and atherosclerotic injuries. HMG-CoA reductase inhibitors (Statins) are first line antihypercholesterolemic drugs and are widely used for management of cardiovascular diseases, though they have severe side effects. Revealing of these drugs side effects are dose-dependent. The literature sources show the possibility to reduce drug dose without reduction of therapeutic effect by combination of statins with natural polyphenols. All the parts of grape vine are rich with polyphenolic compounds, including leaves and shoots; It is especially important to derive natural polyphenols from Georgian grape vines, standardization and study of their influence on statins pharmacokinetics.

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References

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საქართველოს სამკურნალო საშუალებათა რეესტრი - http://pharmacy.moh.gov.ge/Pages/Products.aspx

Published

2021-05-07

How to Cite

Bokuchava N., Murtazashvili T., Sivsivadze K., Gongadze N., & Mitagvaria N. (2021). INFLUENCE OF POLYPHENOLS ON THE BIOAVAILABILITY OF STATINS. COLLECTION OF SCIENTIFIC WORKS OF TBILISI STATE MEDICAL UNIVERSITY, 52. Retrieved from https://journals.4science.ge/index.php/CSW/article/view/355