Prognostic value of hyperuricemia in patients with heart failure
DOI:
https://doi.org/10.52340/spectri.2023.16Keywords:
heart failure, hyperuricemia, sensitivity, specificity, prognostic valueAbstract
In patients with heart failure, hyperuricemia is often observed. The purpose of our study is to determine the relationship of serum uric acid with biochemical characteristics of heart failure and to determine its diagnostic and prognostic value for the outcome of the disease.
Material and methods: the study was based on the results of the study of 117 patients with asymptomatic hyperuricemia who applied to the clinic from September 2019 to January 2022. We determined the relationship between serum uric acid and the characteristics of heart failure, using ROCK analysis we determined the sensitivity and specificity of uric acid for the outcome of heart failure.
Results: Creatinine - r=0.478**, p=0.000 shows a reliable positive correlation with uric acid concentration; CRP - r=0.742**, p=0.000; BNP - r=0.599**, p=0.000, and eGFR - r=-0.184*, p=0.046 shows a reliable negative correlation; According to the degree of heart failure, the concentration of uric acid was distributed as follows: NYHAI - 5.48+0.94; NYHAII - 6.71+1.36; NYHAIII - 8.10+1.14; NYHA IV - 8.78+1.01 (F=29.24, p<0.0001). sensitivity - 00.810(95%CI: 0.709-0.911); specificity - 0.814(95%CI: 0.714-0.913); predictive value of negative result 0.814(95%CI:0.714-0.913); Prognostic value of a positive result - 0.810(95%CI:0.709-0.911); Diagnostic accuracy of the test - 0.812(95%CI:0.741-0.883).
Conclusions:
Serum uric acid values correlate with renal function and heart failure characteristics.
The value of uric acid can be used as an additional test to predict the outcome of heart failure.
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