NEUROVEGETATIVE AND ELECTRO ENCEPHALOGRAPHIC CHANGES IN ADOLESCENTS WITH SUBCLINICAL THYROID DYSFUNCTIONS FROM MILDLY IODINE DEFICIENT AREAS OF GEORGIA

Аннотация

Aims: revelation of peculiarities of neurovegetative function and some electroencephalographic (EEG) changes in adolescents from mildly iodine deficient (ID) regions of Georgia.

Materials and methods: From total of 120 adolescents from regions of Georgia with ID we choose 42 somatically healthy adolescents, aged 13-17y with O - I degree of goiter, 30 persons with subclinical hypothyroidism (Gr.1) and 12 - With subclinical hyperthyreosis (Gr.2). 20 healthy euthyroid adolescents with normal thyroid function (Gr.3) Urinary iodine excretion (UIE) median in the regions they came from was 64,7 and was at the lower third of the diapason for mild iodine deficiency.

Results: 58% of patients with subclinical thyroid disfunctions complained of a headache, anxiety, restlessness, emotional lability, weakness, adynamia, easy fatigue, sleep disturbances and memory loss. Palpitation, coldness and numbness of the extremities.

Objective data: accommodation and convergence disorders in gr.1.2,3 in 5,6, and 1,5% of cases, respectively. Hyporeflexia 12% in gr.1 and 3% in gr.3. 50% of patients with subclinical hyperthyreosis had hyperreflexia, static ataxia in 10, 9, 1% of cases, respectively and decreased sensitivity in 29, 15, 4%, respectively. Vegetodystonia manifested with patasinpaticitonia had 25% of patients of gr.1 and with sympaticotonia in gr.2 1% of gr.3 patients had vegetodistonia predominantly with parasimpaticotonia. 64% of euthyroid patients had normal EEG, 9% - disorganized and 4% desynchronized types. Gr. 1 patients had desynchronized (20%), disorganized (19%) and desynchronized - disorganized (19%) EEG activities. Gr.2 patients had EEG activities – disorganized (40%) and desynchronized (15%)

Conclusion: 1. Even at the background of mild ID develops subclinical thyreopathia, manifested predominantly as hypothyroidism. 2. Subclinical dysfunctions in the adolescents are manifested with some symptoms of the damage of peripheral and central nervous system. 3. Clinical signs of vegetodystonia in adolescents are manifested with parasimpaticotonia in subclinical hypothyroidism and with symphaticotonia in subclinical hyperthyroidism. 4. Neurologic dysfunctions in adolescents, developed at the background of environmental iodine deficiency, are more pronounced in patients with subclinical hypothyroidism and are manifested with the predominance of desynchronized EEG activity.