THE ROLE OF ENERGY BALANCE IN THE DEVELOPMENT OF POLYCYSTIC OVARY SYNDROME

Abstract

Objective. The aim of our study was to evaluate energy parameters in adolescents by the method of indirect calorimetry and to determine their association with PCOS.

Methods. 50 adolescents (age - 13-19 years) with different body mass with PCOS were studied in a cross-sectional study. 50 adolescents with the same body mass and age without PCOS made up the control group. Participants of both groups were interviewed using a specially designed questionnaire to obtain data on food intake, eating habits, sleep and physical activity. Energy indicators were determined by the method of indirect calorimetry with REEVUE Metacheck (KORR^TM, USA) device. Resting Metabolic Rate (RMR) was determined by the ratio of oxygen percentage values ​​in inhaled and exhaled air fractions during 10 minutes. Anthropometric parameters were assessed by calculating body mass index taking into account age and gender (percentile tables, WHO, 2002).

Results. The RMR in the main study group (1758.5±363.7 kcal), as well as in the study subgroups of low body (1603.6±274.0 kcal), normal (1724.2±356.9 kcal) and overweight patients (2088.0±327.2 kcal) was significantly increased compared to the control subgroups. If we compare the RMR rates between the subgroups, it is clear that in the study subgroup of excess body mass and PCOS was significantly increased compared to the study patients with normal and low mass and PCOS (p<0.001), while the rate of the study subgroup of normal mass was not significantly different from the rate of patients with low mass and PCOS (p=0.254). In the study group, a total of 9 (18%) patients had a decreased indicator compared to the indicator calculated by mathematical formulas, which was considered an energy deficient condition. In the subgroups divided by body mass, this condition was distributed as follows: low mass - 6 (33.3%), normal mass - 3 (15.0%). Such a situation was not observed in people with excess body weight.

According to the data obtained from the survey, in terms of behavioral disorders and unbalanced diet, compared to the control group, the study group had a significantly higher chance of: protein-lack and carbohydrate-rich food, breakfast skipping, intermittent sleep, sleep duration (<8 hours) and a sedentary lifestyle.

Conclusion. Based on the results of the research, it can be concluded that energy imbalance is most likely one of the important pathogenic factors in the development of excess body mass and PCOS. In order to turn this assumption into evidence, large-scale randomized clinical trials are needed.