MANIFESTATION OF THE PARTICULARITIES OF THE USAGE FEATURES OF MONOCLONAL ANTIBODIES IN VARIOUS PHARMACOTHERAPEUTIC APPLICATIONS
DOI:
https://doi.org/10.52340/jecm.2023.04.14Ключевые слова:
Usage, features, monoclonal antibodies, clinical, therapeutic, applicationsАннотация
Monoclonal antibodies have been used for the treatment of various severe diseases, such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, cancer infections among others. They have immunomodulatory effects, are prepared against specific cytokines, inhibit specific enzymes or signaling molecules. Monoclonal antibodies are generally well tolerated, but those that suppress the immune system may reactivate latent infections, such as tuberculosis or hepatitis B. Most monoclonal antibodies in oncology are administered in body-size-based dosing schedules. Monoclonal antibody-based immunotherapy is now considered to be a main component of cancer therapy, alongside surgery, radiation, and chemotherapy. Monoclonal antibodies possess a diverse set of clinically relevant mechanisms of action. In addition, antibodies can directly target tumor cells while simultaneously promoting the induction of long-lasting anti-tumor immune responses. The multifaceted properties of antibodies as a therapeutic platform have led to the development of new cancer treatment strategies that will have major impacts on cancer care.
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