MODELS OF CHRONIC PANCREATITIS
DOI:
https://doi.org/10.52340/jecm.2023.02.16Ключевые слова:
Laboratory models, Pancreatitis, acute, chronicАннотация
Laboratory models of acute and chronic pancreatitis in animals are created in order to study the mechanisms of pathogenesis, develop new methods of treatment and carcinogenesis during inflammation of the pancreas. Both in vitro models are used to study the early stage, short-term processes in which acinar cells are involved, as well as models that cause the development of mild or severe forms of the disease in rodents. Although rodents are most commonly used in models of pancreatitis, the pancreatic damage they cause does not necessarily fully correspond to human pathology. Therefore, it is necessary to carefully choose the model most suitable for the answer in this particular task. The purpose of this article is to compare the most widely used animal models of pancreatitis.
Скачивания
Библиографические ссылки
Yamasaki M, Takeyama Y, Shinkai M, et al. Pancreatic and bile duct obstruction exacerbates rat caerulein-induced pancreatitis: a new experimental model of acute hemorrhagic pancreatitis. J Gastroenterol 2006;41:352–360.
Samuel I, Chaudhary A, Fisher RA, et al. Exacerbation of acute pancreatitis by combined cholinergic stimulation and duct obstruction. Am J Surg 2005;190:721–724.
Otani T, Matsukura A, Takamoto T, et al. Effects of pancreatic duct ligation on pancreatic response to bombesin. Am J Physiol Gastrointest Liver Physiol 2006;290:G633–G639.
Miyauchi M, Suda K, et al. Role of fibrosis-related genes and pancreatic duct obstruction in rat pancreatitis models: implications for chronic pancreatitis. Histol Histopathol 2007;22:1119 –1127.
Tanaka T, Miura Y, Matsugu Y, et al. Pancreatic duct obstruction is an aggravating factor in the canine model of chronic alcoholic pancreatitis. Gastroenterology 1998;115:1248 –1253.
Neuschwander-Tetri BA, Bridle KR, et al. Repetitive acute pancreatic injury in the mouse induces procollagen alpha1(I) expression colocalized to pancreatic stellate cells. Lab Invest 2000;80:143–150.
Guerra C, Schuhmacher AJ, Canamero M, et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 2007;11:291–302.
Watanabe T, Masamune A, Kikuta K, et al. Bone marrow contributes to the population of pancreatic stellate cells in mice.Am J Physiol Gastrointest Liver Physiol 2009;297:G1138 –G1146.
Treiber M, Neuhofer P, Anetsberger E, et al. Myeloid, but not pancreatic, RelA/p65 is required for fibrosis in a mouse model of chronic pancreatitis. Gastroenterology 2011;141:1473–1485,1485.e1–7.
Charrier AL, Brigstock DR. Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis. Lab Invest 2010;90:1179 –1188.
Vonlaufen A, Xu Z, et al. Bacterial endotoxin: a trigger factor for alcoholic pancreatitis? Evidence from a novel, physiologically relevant animal model. Gastroenterology 2007;133:1293–1303.
Vonlaufen A, Phillips PA, Xu Z, et al. Withdrawal of alcohol promotes regression while continued alcohol intake promotes persistence of LPS-induced pancreatic injury in alcohol-fed rats.Gut 2011;60:238 –246.
Sparmann G, Merkord J, Jaschke A, et al. Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride. Gastroenterology 1997;112:1664 –1672.
Chen Q, Vera-Portocarrero LP, Ossipov MH, et al. Attenuation of persistent experimental pancreatitis pain by a bradykinin b2 receptor antagonist. Pancreas 2010;39:1220 –1225.
Vardanyan M, Melemedjian OK, Price TJ, et al. Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain 2010;151:257–265.
Puig-Divi V, Molero X, Salas A, et al. Induction of chronic pancreatic disease by trinitrobenzene sulfonic acid infusion into rat pancreatic ducts. Pancreas 1996;13:417– 424.
Zhu Y, Mehta K, Li C, et al. Systemic administration of anti-NGF increases A-type potassium currents and decreases pancreatic nociceptor excitability in a rat model of chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol 2012;302:G176 –G181.
Ida S, Ohmuraya M, Hirota M, et al. Chronic pancreatitis in mice by treatment with choline-deficient ethionine-supplemented diet.Exp Anim 2010;59:421– 429.
Dimagno MJ, Lee SH, Hao Y, et al. A proinflammatory, antiapoptotic phenotype underlies the susceptibility to acute pancreatitis in cystic fibrosis transmembrane regulator (-/-) mice. Gastroenterology 2005;129:665–681.
Meyerholz DK, Stoltz DA, Pezzulo AA, et al. Pathology of gastrointestinal organs in a porcine model of cystic fibrosis. Am J Pathol 2010;176:1377–1389.
Abu-El-Haija M, Ramachandran S, et al. Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways. Am J Pathol 2012;181:499 –507.
Marrache F, Tu SP, Bhagat G, et al. Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis. Gastroenterology 2008;135:1277–1287.
Ji B, Tsou L, Wang H, et al. Ras activity levels control the development of pancreatic diseases. Gastroenterology 2009; 137:1072–1082, 1082.e1– 6.
Daniluk J, Liu Y, Deng D, et al. An NF-kappaB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. J Clin Invest 2012;122:1519 –1528.
Park SW, Davison JM, Rhee J, et al. Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology 2008;134:2080 –2090.
Zhang L, Chari S, Smyrk TC, et al. Autoimmune pancreatitis (AIP) type 1 and type 2: an international consensus study on histopathologic diagnostic criteria. Pancreas 2011;40:1172–1179.
Uchida K, Okazaki K, et al. Experimental immune-mediated pancreatitis in neonatally thymecto-mized mice immunized with carbonic anhydrase II and lactoferrin. Lab Invest 2002; 82: 411–424.
Haruta I, Shimizu K, Yanagisawa N, et al. Commensal flora, is it an unwelcomed companion as a triggering factor of autoimmune pancreatitis? Front Physiol 2012;3:77.
Navina S, Acharya C, DeLany JP, et al. Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity. Sci Transl Med 2011;3:107ra110.
Sennello JA, Fayad
Загрузки
Опубликован
Как цитировать
Выпуск
Раздел
