PHARMACOLOGICAL ASSESSMENT OF CONSTITUENTS OF SPECIES ALLIUM SAXATILE AND ALLIUM PONTICUM GROWING IN GEORGIA
DOI:
https://doi.org/10.52340/jecm.2022.06.04Ключевые слова:
Allium saxatile, Allium ponticum, Analgesic activity, Anti-inflammatory activity, Gastroprotective activityАннотация
The present study aimed to estimate pharmacological potency of products from some Allium species - Allium saxatile and Allium ponticum, growing in Georgia. Analgesic, anti-inflammatory and gastroprotective activity of total extracts and fractions from was evaluated using accepted in vivo models: hot-plate, carrageenan induced oedema and ethanol induced gastric ulcer, respectively. The results of the experiments have revealed valuable effects of the total extracts and fractions obtained from A. saxatile and A. ponticum. In particular, A. saxatile total extract demonstrated moderately ascending prolonged analgesic activity (70.3%), whereas total extract of A.ponticum exhibited rapid, high, but shortlasting effect (105%). Same tendency was noticed when fractions were studied. Similarly, A. saxatile total extract and its fractions appeared more effective (63.5%), than one obtained from A.ponticum (32.7%) in carrageenan induced paw oedema model. In ethanol induced gastric ulcer model only A. saxatile appeared to effectively reduce ulcer index (UI) by 44%, when A. ponticum extract, oppositely, increased ulcer index (UI). Summarizing the results, it can be concluded that the study revealed A.saxatile and A.ponticum as a promising raw of bioactive compounds for drug development.
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