THE SIGNIFICANCE OF THE STUDY OF THE LIVER FUNCTION TEST WITHIN POST-TRANSPLANT PATIENTS
Keywords:Liver function test, Transplantation, Liver
In recent years, the survival rate of patients after liver transplantation (LT) has improved significantly. However, successful transplantation is directly related to the proper management of the patient after surgery, including considering essential aspects based on the results of laboratory tests. Therefore, it is essential to study the laboratory characteristics to investigate the functional state of the liver. In the present study, we investigated the indicators of liver function in postoperative patients: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, total bilirubin, gamma-glutamyl transferase (GGT). Venous blood samples were used for investigation. A total of 10 post-transplant patients were studied. Appropriate research methods were used. P<0.05 was considered statistically significant. Overall, our results have shown that intensive examinations of the liver panel in postoperative patients significantly contribute to the proper management of the complicated patient, which directly impacts the final results. Notably, the variability of GGT and ALP may be directly related to the transplanted chronic immune response of the liver and may be used as an early marker for the diagnosis of biliary complications.
Pagana, KD., Pagana TJ. Diagnostic and Laboratory Test Reference. St. Louis. Dimensions of Critical Care Nursing. 1993
C.K., Opio, Seremba E., Ocama P., Lalitha R., Kagimu M., L. Rejani, M. Kagimu, W.M. Lee. “Diagnosis of Alcohol Misuse and Alcoholic Liver Disease among Patients in the Medical Emergency Admission Service of a Large Urban Hospital in Sub-Saharan Africa; a Cross Sectional Study.” Pan African Medical Journal, 2013
McPherson, Richard A., Matthew R. Pincus. 2011. Chapter 16: Carbohydrates. In: Henry’s Clinical Diagnosis and Management by Laboratory Methods. 22nd Ed. Pp 210-225.
STARZL, T.E., T.L. MARCHIORO, K.N. VONKAULLA, G. HERMANN, R.S. BRITTAIN, W.R. WADDELL. “HOMOTRANSPLANTATION OF THE LIVER IN HUMANS.” Surgery, Gynecology & Obstetrics, 1963.
Toro, Adriana, Annalisa Ardiri, Maurizio Mannino, Maria Concetta Arcerito, Giovanni Mannino, Filippo Palermo, Gaetano Bertino, Isidoro Di Carlo. “Effect of Pre- and Post-Treatment α-Fetoprotein Levels and Tumor Size on Survival of Patients with Hepatocellular Carcinoma Treated by Resection, Transarterial Chemoembolization or Radiofrequency Ablation: A Retrospective Study.” BMC Surgery, 2014.
Westwood, A. “The Analysis of Bilirubin in Serum.” Annals of Clinical Biochemistry. 1991.
Burtis CA, Ashwood ER, Burns DE. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 4th ed. St. Louis: Elsevier Saunders; 2006
Ruttmann E, Brant LJ, Concin H, Diem G, Rapp K, Ulmer H. Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163,944 Austrian adults. Circulation. 2005 Oct 4. 112(14):2130-7
Chernecky CC, Berger BJ. Laboratory Tests and Diagnostic Procedures. 6th ed. Philadelphia, Pa: Elsevier Saunders; 2013
Burtis CA, Ashwood MD. Tietz Textbook of Clinical Chemistry. 3rd ed. Saunders; 1999
Pagana KD, Pagana TJ, Pagana TN. Mosby’s Diagnostic & Laboratory Test Reference. 14th ed. St. Louis, Mo: Elsevier; 2019