PEMPHIGUS VULGARIS: A CLINICAL CASE DISCUSSION

Authors

IRINA MUSERIDZE Tbilisi State Medical University
MARIAMI DAVLASHERIDZE Tbilisi State Medical University
SALOME KHIMSHIASHVILI Tbilisi State Medical University
ALEXANDER KATSITADZE Tbilisi State Medical University
NATO KORSANTIA Tbilisi State Medical University

DOI:

https://doi.org/10.52340/jecm.2026.02.15

Keywords:

Pemphigus, Acantholysis, Intraepidermal blister, Desmoglein, Nikolsky sign

Abstract

Pemphigus is a group of autoimmune blistering disorders affecting the skin and mucous membranes, characterized by intraepidermal blister formation caused by acantholysis and autoantibodies directed against keratinocyte cell surfaces. The major forms include Pemphigus vulgaris, Pemphigus foliaceus, paraneoplastic pemphigus, and IgA pemphigus. In pemphigus vulgaris, blistering occurs in the deeper epidermal layers above the basal layer, whereas pemphigus foliaceus involves more superficial blister formation within the granular layer.

The discovery by Beutner and Jordon in 1964 of circulating antibodies against the cell surface of keratinocytes in the sera of patients with Pemphigus vulgaris established that PV is a tissue-specific autoimmune disease of the skin and mucosa. Their work ultimately led to the identification of autoantibodies in other autoimmune bullous diseases of the skin.

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Author Biographies

IRINA MUSERIDZE, Tbilisi State Medical University

Tbilisi State Medical University, Department of Dermatology and Venereology, Tbilisi, Georgia

MARIAMI DAVLASHERIDZE, Tbilisi State Medical University

Tbilisi State Medical University, Department of Dermatology and Venereology, Tbilisi, Georgia

SALOME KHIMSHIASHVILI, Tbilisi State Medical University

Tbilisi State Medical University, Department of Dermatology and Venereology, Tbilisi, Georgia

ALEXANDER KATSITADZE, Tbilisi State Medical University

Tbilisi State Medical University, Department of Dermatology and Venereology, Tbilisi, Georgia

NATO KORSANTIA, Tbilisi State Medical University

Tbilisi State Medical University, Department of Dermatology and Venereology, Tbilisi, Georgia

References

Fitzpatrick’s Dermatology in General Medicine 7th edition - Pemphigus P. 459-460

Rook’s Textbook of Dermatology 7th edition, volume 1, Pemphigus vulgaris Chapter 41.5, page 2009

Joly P, Horvath B, Patsatsi Α, Uzun S, Bech R, Beissert S et al. Updated S2K guidelines on the management of pemphigus vulgaris and foliaceus initiated by the european academy of dermatology and venereology (EADV). J Eur Acad Dermatol Venereol. 2020 Sep;34(9):1900-1913. doi: 10.1111/jdv.16752. Epub 2020 Aug 24. PMID: 32830877.

Andrews' Diseases of the Skin - Clinical Dermatology James William D., Elston Dirk M. 2025. Chronic Blistering Dermatoses page 472-475

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Published

2026-06-02

How to Cite

MUSERIDZE, I., DAVLASHERIDZE, M., KHIMSHIASHVILI, S., KATSITADZE, A., & KORSANTIA, N. (2026). PEMPHIGUS VULGARIS: A CLINICAL CASE DISCUSSION. Experimental and Clinical Medicine Georgia, (2), 92–95. https://doi.org/10.52340/jecm.2026.02.15

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