LEAD DISTRIBUTION IN PATIENTS WITH ALLERGIC DISEASES – A SEVEN-YEAR EPIDERMIOLOGICAL STUDY

NANA SHAVLAKADZE; ANA SILAGADZE

doi:10.52340/jecm.2025.03.05

LEAD DISTRIBUTION IN PATIENTS WITH ALLERGIC DISEASES – A SEVEN-YEAR EPIDERMIOLOGICAL STUDY

Authors

NANA SHAVLAKADZE Clinic "XXI SAUKUNE"
ANA SILAGADZE Clinic "XXI SAUKUNE"

DOI:

https://doi.org/10.52340/jecm.2025.03.05

Keywords:

Lead, allergy, environmental toxicology, immunological markers, body burden, BLL, children, asthma, urticaria, food allergy

Abstract

Objective: To evaluate the potential association between lead, as an environmental toxic agent, and the clinical manifestations of allergic diseases.

Methods: As part of a multi-year cross-sectional study, lead levels and immunological parameters were assessed in 418 allergic patients and 92 healthy controls. Biochemical and immunological analyses were performed using modern laboratory techniques (ICP-MS, ELISA, immunofluorescence), and statistical analysis was conducted using STATA 18.

Results: Lead concentration was significantly higher in the allergic patient group (BLL >10 µg/dL observed in 72%), especially among children. Levels of IgE, histamine, and anti-IgE, as well as eosinophil counts, were significantly elevated in the allergic group (p < 0.05).

Conclusion: Elevated lead levels may be associated with the allergic sensitization process, particularly in pediatric patients, highlighting the need for environmental health protection.

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Author Biography

NANA SHAVLAKADZE, Clinic "XXI SAUKUNE"

Akaki Tsereteli State University, Faculty of Medicine, Kutaisi, Georgia

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