IMPACT OF THE BOTULINUM NEUROTOXIN INJECTIONS ON PATIENTS WITH DEPRESSION: THERAPEUTIC MECHANISMS AND POSSIBLE FUTURE PERSPECTIVE

NATO KAKABADZE; NERIMAN TSINTSADZE; MIKHEIL ARTMELADZE; ALBINA KADJAIA; MURAT TSINTSADZE; NINO TSINTSADZE

doi:10.52340/jecm.2024.05.19

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2026-01-29

IMPACT OF THE BOTULINUM NEUROTOXIN INJECTIONS ON PATIENTS WITH DEPRESSION: THERAPEUTIC MECHANISMS AND POSSIBLE FUTURE PERSPECTIVE

Authors

NATO KAKABADZE Avicenna - Batumi Medical UniversityBatumi, Georgia
NERIMAN TSINTSADZE Avicenna - Batumi Medical UniversityBatumi, Georgia
MIKHEIL ARTMELADZE Avicenna - Batumi Medical UniversityBatumi, Georgia
ALBINA KADJAIA Total Charm Vake, Tbilisi, Georgia
MURAT TSINTSADZE Total Charm Vake, Tbilisi, Georgia
NINO TSINTSADZE Avicenna - Batumi Medical UniversityBatumi, Georgia

DOI:

https://doi.org/10.52340/jecm.2024.05.19

Keywords:

depression, botulinum neurotoxin, therapy, facial feedback, Beck Depression Inventory (BDI)

Abstract

Background: Despite the fact that today's medicine is constantly developing in all directions, there are still some diseases that burden humanity and interfere with daily life, like Depression. Existing treatment tactics are often ineffective, and Botox injections in such cases are an experimental method.

Objectives: Our goal is to review previous researches and make this information available on a larger scale so that clinicians can access similar therapies for use in unconventional cases. The purpose of the study was not to directly cure depression, but to evaluate the positive impact that manipulations carried out for aesthetic purposes would have on their general mood and condition. Our attention was especially drawn to the fact that research on this topic has not been conducted in our country yet.

Methods: The study involved 15 participants and it lasted on average two months. The Beck Depression Inventory (BDI) Questionnaire, in total 21 question, was used for assessment, just like our predecessors.

Results: The results, to our delight, gave us very interesting feedback, based on which we can assume the positive contribution of Botox in the management of patients with depression. BoNT/A injections led to significant improvement of self-rated depression score by using Beck Depression Inventory (BDI). The response rates of BoNT/A were 34%. From the literature, we know that positive results in previous studies ranged from 13% to 52%.

Conclusion: Botulinum Neurotoxin therapy shows promise as a novel approach to treating depression. While further research is needed to establish its effectiveness, Botox may offer a unique and potentially valuable option for individuals struggling with depression.

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References

R.H. McAllister-Williams, C. Arango, et al. The identification, assessment and management of difficult-to-treat depression: an international consensus statement. J Affect Disord, 267 (2020), 264-82

https://www.sciencedirect.com/science/article/pii/S0165032719321925

The 2019 Global Burden of Disease (GBD) study. https://vizhub.healthdata.org/gbd-results/

What is Electroconvulsive Therapy (ECT)? William McDonald, Laura Fochtmann et al. January 2023 https://www.psychiatry.org/patients-families/ect

Jennifer Coughlin, Ana Soule, Treatment-Resistant Depression, CRNP

https://www.hopkinsmedicine.org/health/conditions-and-diseases/mood-disorders/treatment-resistant-depression

Treatment-resistant depression-Sometimes depression doesn't get better, even with treatment. https://www.mayoclinic.org/diseases-conditions/depression/in-depth/treatment-resistant-depression/art-20044324

Thase M, et al. Unipolar depression in adults: Treatment of resistant depression. https://www.uptodate.com/home. Accessed March 1, 2021.

ECT, TMS and other brain stimulation therapies. National Alliance on Mental Illness. https://www.nami.org/Learn-More/Treatment/ECT,-TMS-and-Other-Brain-Stimulation-Therapies. Accessed March 1, 2021

Botulinum toxin (Botox) A for reducing the appearance of facial wrinkles: a literature review of clinical use and pharmacological aspect Bagus Komang Satriyasa

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489637/

Marc Axel Wollmer, Michelle Magid, Tillmann H. C. Kruger, Eric Finzi. Treatment of Depression with Botulinum Toxin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231293/#:~:text=Botulinum%20toxin%20injection%20into%20the,clinical%20trials%20and%20meta%2Danalyses.

A Lagueny, P Burbaud. Mechanism of action, clinical indication and results of treatment of botulinum toxin.

https://pubmed.ncbi.nlm.nih.gov/8975111/#:~:text=Botulinum%20toxin%2C%20the%20most%20potent,inducing%20partial%20paralysis%20and%20atrophy.

Becky J Proskocil, Harmanjatinder S Sekhon, Yibing Jia, Valentina Savchenko, Randy D Blakely, Jon Lindstrom, Eliot R Spindel. Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells

https://pubmed.ncbi.nlm.nih.gov/14764638/#:~:text=The%20role%20of%20acetylcholine%20(ACh,a%20variety%20of%20nonneuronal%20tissues.

L. C. Bulnes, P. Mariën, M. Vandekerckhove, A. Cleeremans. The effects of Botulinum toxin on the detection of gradual changes in facial emotion

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692314/

Jara Schulze, Insa Neumann, Michelle Magid, Eric Finzi, Christopher Sinke, M. Axel Wollmer, Tillmann H.C. Krüger. Botulinum toxin for the management of depression: An updated review of the evidence and meta-analysis.

https://www.sciencedirect.com/science/article/abs/pii/S0022395621000236

Toren P. Stearns, Mujeeb U. Shad, Gabriela C. Guzman, AA. Glabellar Botulinum Toxin Injections in Major Depressive Disorder: A Critical Review. https://www.psychiatrist.com/pcc/glabellar-botulinum-for-depression/

Nicole Washington, Hilary I. Lebow. Can Botox Help with Depression? on August 30, 2021. https://psychcentral.com/depression/botox-for-depression#next-steps

Botulinum Toxin Treatment for Depression: A New Paradigm for Psychiatry by Eric Finzi. https://www.mdpi.com/2072-6651/15/5/336

Jean-Paul Macher, Marc-Antoine Crocq, Treatment goals: response and nonresponse. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181789/#:~:text=Response%20to%20treatment%20supposes%20that,the%20initial%20score%20is%20significant.

Haim M. Solomon, Timothy Lilly, Jr. Bacteriological Analytical Manual (BAM) Main Page. Jan 2001.

https://www.fda.gov/food/laboratory-methods-food/bam-chapter-17-clostridium-botulinum#:~:text=Clostridium%20botulinum%20is%20an%20anaerobic,toxin%2Dcontaining%20foods%20are%20ingested.

Sven Söderkvist, Kajsa Ohlén, Ulf Dimberg. How the Experience of Emotion is Modulated by Facial Feedback https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816132/

Andreas Hennenlotter, Christian Dresel, Florian Castrop, Andres O. Ceballos-Baumann, Afra M. Wohlschläger, Bernhard Haslinger. The Link between Facial Feedback and Neural Activity within Central Circuitries of Emotion—New Insights from Botulinum Toxin–Induced Denervation of Frown Muscles

https://academic.oup.com/cercor/article/19/3/537/429135?login=false

Kim, M.J.; Neta, M.; Davis, F.C.; Ruberry, E.J.; Dinescu, D.; Heatherton, T.F.; Stotland, M.A.; Whalen, P.J. Botulinum toxin-induced facial muscle paralysis affects amygdala responses to the perception of emotional expressions: Preliminary findings from an A-B-A design. Biol. Mood Anxiety Disord. 2014, 4, 11.

Hyeon Joo Ham, In Jun Yeo, Seong Hee Jeon, Jun Hyung Lim, Sung Sik Yoo, Dong Ju Son, Sung-Su Jang, Haksup Lee, Seung-Jin Shin, Sang Bae Han, Jae Suk Yun, and Jin Tae Hong, Botulinum Toxin A Ameliorates Neuroinflammation in the MPTP and 6-OHDA-Induced Parkinson’s Disease Models https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724835/

Li, Y., Liu, T., & Luo, W. (2021). Botulinum Neurotoxin Therapy for Depression: Therapeutic Mechanisms and Future Perspective. Frontiers in Psychiatry, 12.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102733/

Lyu Alan FY, Lulu T, Xueyan G, Jing L, Yixian H, Xuping Z, et al. Clinical study on the efficacy and safety of botulinumtoxin A in the treatment of Parkinson′ s disease with depression. Chin J Neurol. (2019) 52:745–51.

Finzi E, Rosenthal NE. Treatment of depression with a botulinumtoxinA: a randomized, double-blind, placebo-controlled trial. J Psychiatr Res. (2014) 52:1–6. doi: 10.1016/j.jpsychires.2013.11.006.

https://static1.squarespace.com/static/619e69307b82584151d39120/t/61e66e0e228da66cae170bd4/1642491407579/Finzi+and+Rosenthal%2C+RCT+.pdf

Chugh S, Chhabria A, Jung S, Kruger THC, Wollmer MA. Botulinum toxin as a treatment for depression in a real-world setting. J Psychiatr Pract. (2018) 24:15–20. doi: 10.1097/pra.0000000000000277

Lewis MB, Bowler PJ. Botulinum toxin cosmetic therapy correlates with a more positive mood. J Cosmet Dermatol. (2009) 8:24–6. doi: 10.1111/j.1473-2165.2009.00419.x

MagidM, Reichenberg JS, Poth PE, Robertson HT, LaViolette AK, Kruger TH, et al. Treatment of major depressive disorder using botulinum toxin A: a 24-week randomized, double-blind, placebo-controlled study. J Clin Psychiatry. (2014) 75:837–44. doi: 10.4088/JCP.13m08845

Yogesh Dwivedi. Brain-derived neurotrophic factor: role in depression and suicide Neuropsychiatr Dis Treat. 2009; 5: 433–449. doi: 10.2147/ndt.s5700

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Published

2024-09-15

How to Cite

KAKABADZE, N., TSINTSADZE, N., ARTMELADZE, M., KADJAIA, A., TSINTSADZE, M., & TSINTSADZE, N. (2024). IMPACT OF THE BOTULINUM NEUROTOXIN INJECTIONS ON PATIENTS WITH DEPRESSION: THERAPEUTIC MECHANISMS AND POSSIBLE FUTURE PERSPECTIVE. Experimental and Clinical Medicine Georgia, (5), 117–125. https://doi.org/10.52340/jecm.2024.05.19

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IMPACT OF THE BOTULINUM NEUROTOXIN INJECTIONS ON PATIENTS WITH DEPRESSION: THERAPEUTIC MECHANISMS AND POSSIBLE FUTURE PERSPECTIVE

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