ULTRASTRUCTURAL CHANGES IN THE PENUMBRA OF THE LOCAL CEREBRAL INFARCTION IN RATS DURING THE FIRST TWELVE HOURS

ULTRASTRUCTURAL CHANGES IN THE PENUMBRA OF THE LOCAL CEREBRAL INFARCTION IN RATS DURING THE FIRST TWELVE HOURS

Authors

  • NATALIA CATHERINE HARGREAVES Tbilisi State Medical University
  • RAMAZ KHETSURIANI Tbilisi State Medical University
  • MANANA ARABULI-TCHLIKADZE Tbilisi State Medical University
  • ANZOR GOGIBERIDZE Tbilisi State Medical University
  • NODAR MITAGVARIA I. Beritashvili Institute of Physiology

DOI:

https://doi.org/10.52340/jecm.2022.08.12

Keywords:

local cerebral infarction, penumbra, synapses, myelinated nerve fiber

Abstract

We studied changes in the ultrastructure of synapses and myelin nerve fibers that develop in the penumbra in 4 and 12 hours after modeling infarction in the frontoparietal cortex in rats. Ischemic stroke was induced by injection of a photosensitive dye into their bloodstream followed by illumination of the brain surface with a halogen lamp. Visible ultrastructural changes were observed in the penumbra zone, namely in the axodendritic and axospinous synapses; they consisted in polymorphism and disorganization of synaptic vesicles, mitochondrial swelling, swelling and vacuolization of the postsynaptic fragments of dendrites, and shortening and osmiophilia of the active zone. In the presynaptic terminals, clear-cut signs of transformation were not observed during the first 12 hours. It indicates the necessity of early treatment of strokes.

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References

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Published

2022-12-07

How to Cite

HARGREAVES , N. C., KHETSURIANI, R., ARABULI-TCHLIKADZE, M., GOGIBERIDZE, A., & MITAGVARIA, N. (2022). ULTRASTRUCTURAL CHANGES IN THE PENUMBRA OF THE LOCAL CEREBRAL INFARCTION IN RATS DURING THE FIRST TWELVE HOURS. Experimental and Clinical Medicine Georgia, (8). https://doi.org/10.52340/jecm.2022.08.12

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