RADIOPROTECTIVE PROPERTIES OF VENOM OF TRANSCAUCASIAN VIPERA (MACROVIPERA LEBETINA OBTUSA DYIGUBSKY, 1832)
DOI:
https://doi.org/10.52340/jecm.2022.07.10Keywords:
venom, radioprotective properties, Macrovipera lebetina obtusa, gamma irradiationAbstract
The article presents experimental data on the study of the anti-ray effect of venom of Transcaucasian vipera (Macrovipera lebetina obtusa), which is based on nonspecific mechanisms of the activation reaction. The results of the study showed that snake venom has a pronounced radioprotective effect. It was found experimentally that, in fractional gamma irradiation of mice at doses of 1.2, 3, 4, 5, 6 Gy, followed by 2 mg / kg and 4 mg / kg of poisoning, observed an increase in the life span of mice from 28-30 and 15 -20 minutes to 50.0 ± 2.7, 95.0 ± 6.2; 60.0 ± 5.3, 100.0 ± 8.1; 70.0 ± 15.1, 130.0 ± 12.5; 85.0 ± 11.5, 170.0 ± 19.3; 95.0 ± 13.5, 200.0 ± 29.0; 110.0 ± 15.5, 250.0 ± 20.7 minutes respectively. The results of the study of the radio protective properties of snake venom revealed that venom of Transcaucasian vipera (Macrovipera lebetina obtusa), at injection in a non-toxic dose, is a long-acting radio protector capable of effectively protecting living organisms from fractional gamma irradiation.
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