Аннотация
Osteoarthritis represents a severe joint disease, that is characterized by an inflammatory reaction in every component of joint. During osteoarthritis for the realization of inflammatory reaction, excess amount of VEGF (vascular endothelial growth factor) is produced, that causes neovascularisation and ingrowth of blood-vessels in the joint cartilage: in superficial surfaces – from connective tissue and in basal layers – from subchondral bone. Ingrowth of blood-vessels in the hyaline cartilage causes firstly superficial and then profound damage, that ends with complete disorganization of cartilage. Ingrowth of blood vessels in cartilage tissue leads to its oxygenation rise, that causes calcification and metaplasy as bone tissue, that is finally followed by complete joint cartilage degradation and subchondral bone exposure. Based on the study result analysis,we can conclude that during osteoarthritis in the progressive damage and degradation of cartilage its vascularization process plays a considerable role.
Библиографические ссылки
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