How to Cite

ცისკარიშვილი ნ.ი. T. N., კაციტაძე ა. K. A., ცისკარიშვილი ნ.ვ. T. N., ცისკარიშვილი ც. T. T., & ჭითანავა ლ. C. L. (2021). OXIDATIVE STRESS IN THE PATHOGENESIS OF VITILIGO. Collection of Scientific Works of Tbilisi State Medical University, 50, 115–117. Retrieved from https://journals.4science.ge/index.php/CSW/article/view/49


The author has presented a short literary review of one of the pathogenetic theories of vitiligo (theory of biochemical alterations), which is based on the oxidative stress. According to this theory, accumulation of the toxic free radicals in the melanocytes induces their destruction. High concentration of Nitric Oxigen (NO) in melanocytes and in serum of vitiligo patients confirms the possible role of this oxidant in melanocytic self-destruction. The increased level of free radicals in melanocytes can provoke defective apoptosis with the subsequent release of aberrant proteins.  These proteins play a role of autoantigens, which in turn actuates the autoimmune reactions. Revealed intracellular reliable imbalance in the antioxidative equilibrium along with the destruction of epidermal cells indicates the significant role of the oxidative stress in the pathogenesis of vitiligo, and data about positive effect of antioxidants in the treatment of vitiligo confirm the participation of oxidative stress in the complicated pathogenesis of vitiligo.



ცისკარიშვილი ნ. ვიტილიგოს ეტიოლოგიისა და პათოგენეზის თანამედროვე კონცეფციები, თსსუ-ის სამეცნიერო შრომათა კრებული, 2012, გვ. 101 -194

Ломоносов К.М. и соавт., Окислительный стресс в патогенезе витилиго, Росс. журн. кож. и вен.бол., 2011 . №1, ст. 68 -70

Лоуэлл А и соавт., Дерматология Фицпатрика в клинической практике. Москва, 2015,том 1. ст. 878 -891

Briganti S, Caron -Schreinemachers A -LDB, Picardo M Westerhof M Anti -oxidant defence

Barygina V. et all. Melanocyte NADPH OXIDASE activation induced by keratinocyte -derived ROS Vitiligo International Symposium Rome , 2-3 December, 2016, Abstracts

Piguero -Casals J., Martinez -Martinez L. et all, The innate immune receptor CD91 and levels of erythrocyte malonyldialdehyde (MDA) as activity markers of vitiligo, Vitiligo International Symposium Rome, 2-3 December, 2016, Abstracts

Picardo M. Non immunological mechanisms in the pathogenesis of vitiligo, An overview. JEADV 2009: 42; 23-31

Picardo M, Taib A, eds. Vitiligo. Berlin, Heidelberg; Springer, 2010

Taieb A, Picardo M. Clinical practice. Vitiligo. Engl. J. Med., 2009; 360;160 -169

Pistone G., Bongiarno M. May the plasmatic antioxidant capacity associated with dermoscopic observation be a useful parameter to value the repigmentation in patients with vitiligo. Vitiligo International Symposium Rome, 2-3 December, 2016, Abstracts

Tsiskarishvili N.I. The mysteries of vitiligo, Tbilisi, 2016


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