How to Cite

Kandashvili, T., Noniashvili, M., Dvalishvili, S., & Tsitsiashvili, K. (2023). KIDNEY INJURY IN COVID-19 PATINETS. Collection of Scientific Works of Tbilisi State Medical University, 56, 157–160. Retrieved from


The purpose of the study: In this study, we aimed to investigate pathological changes in kidney function during the course of COVID-19 in patients who have never been diagnosed with kidney disease before and were hospitalized after at least 24 hours from the first symptoms of Covid-19. Methods: In this retrospective study we collected and analyzed demographics, underlying diseases, signs, symptoms and laboratory data of 71 Covid-19 patients based on The First University Clinic database. All of them were hospitalized after at least 24 hours from the first symptoms of Covid-19. Patients were divided into three groups: mild, moderate and severe group. Kidney injury was evaluated by markers including estimated glomerular filtration rate(eGFR), serum creatinine and blood urea nitrogen. Results: A total of 71 patients with 22 mild, 39 moderate and 10 severe COVID-19 were included in this study. During hospitalization, the level of creatinine was increased in 41% and blood urea nitrogen was increased in 15% of patients. Also, eGFR was decreased in 57% of patients. The average variable of eGFR was 46,7 mL/min/1,73m2. The kidney injury markers, including eGFR, serum creatinine and blood urea nitrogen all worsened with an increase in disease severity. Acute kidney injury was not demonstrated in either of the patients age groups. Conclusion: Worsened eGFR, serum creatinine and blood urea nitrogen levels in patients, who have never been diagnosed with kidney disease before and have Covid-19 symptoms for more than 24 hours, show that altered kidney function is associated with SARS-CoV-2. Although, it is necessary to determine new biomarkers of kidney injury in COVID-19 patients to establish an optimal treatment strategy.



Armutcu F. Organ crosstalk: the potent roles of inflammation and fibrotic changes in the course of organ interactions. Inflamm Res. 2019 Oct;68(10):825-839. doi: 10.1007/s00011-019-01271-7. Epub 2019 Jul 20. PMID: 31327029.

Chen LD, Hu L, Song Y, Huang YP, Yang SJ, Yang J, Zhang XB. Role of serum IL-6 and TNF-á in coronavirus disease 2019 (COVID-19) associated renal impairment. European Journal of Inflammation. 2022 Sep 9;20:1721727X221126117. doi: 10.1177/1721727X221126117.

PMCID: PMC9464930.

Delanghe JR, Speeckaert MM, De Buyzere ML. The host’s angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections. Clin Chim Acta. 2020 Jun;505:192-193. doi: 10.1016/j.cca.2020.03.031. Epub 2020 Mar 24. PMID: 32220422; PM-CID: PMC7102561.

Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020 Apr

;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5. PMID: 32142651; PMCID: PMC7102627.

Joannidis M, Forni LG, Klein SJ, Honore PM, Kashani K, Ostermann M, Prowle J, Bagshaw SM, Cantaluppi V, Darmon M, Ding X, Fuhrmann V, Hoste E, Husain-Syed F, Lubnow M, Maggiorini M, Meersch M, Murray PT, Ricci Z, Singbartl K, Staudinger T, Welte T, Ronco C, Kellum JA. Lung-

kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup.

Intensive Care Med. 2020 Apr;46(4):654-672. doi: 10.1007/s00134-019-05869-7. Epub 2019 Dec 9. PMID: 31820034;PMCID: PMC7103017.

Legrand M, Bell S, Forni L, Joannidis M, Koyner JL, Liu K, Cantaluppi V. Pathophysiology of COVID-19-associated acute kidney injury. Nat Rev Nephrol. 2021 Nov;17(11):751-764. doi: 10.1038/s41581-021-00452-0. Epub 2021 Jul 5. PMID: 34226718; PMCID: PMC8256398.

Nadim, M.K., Forni, L.G., Mehta, R.L. et al. COVID-19 associated acute kidney injury: consensus report of the 25th

Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol 16, 747–764 (2020).

Noris M, Benigni A, Remuzzi G. The case of complement activation in COVID-19 multiorgan impact. Kidney Int. 2020 Aug;98 (2):314-322. doi: 10.1016/j.kint.2020.05.013. Epub 2020 May 24. PMID: 32461141; PMCID: PMC7246017.

Rabb H. Kidney diseases in the time of COVID-19: major challenges to patient care. J Clin Invest. 2020 Jun

;130(6): 2749-2751. doi: 10.1172/JCI138871. PMID : 32250968; PMCID : PMC7259985.

Su H, Yang M, Wan C, Yi LX, Tang F, Zhu HY, Yi F, Yang HC, Fogo AB, Nie X, Zhang C. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 2020 Jul;98(1):219-227. doi: 10.1016/j.kint.2020.04.003. Epub 2020 Apr 9. PMID: 32327202; PM-CID: PMC7194105.

Teixeira JP, Barone S, Zahedi K, Soleimani M. Kidney Injury in COVID-19: Epidemiology, Molecular Mechanisms and Potential Therapeutic Targets. Int J Mol Sci. 2022 Feb 17;23(4):2242. doi: 10.3390/ijms23042242. PMID: 35216358;PMCID: PMC8877127.


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