Abstract
The purpose of the study: In this study, we aimed to investigate pathological changes in kidney function during the course of COVID-19 in patients who have never been diagnosed with kidney disease before and were hospitalized after at least 24 hours from the first symptoms of Covid-19. Methods: In this retrospective study we collected and analyzed demographics, underlying diseases, signs, symptoms and laboratory data of 71 Covid-19 patients based on The First University Clinic database. All of them were hospitalized after at least 24 hours from the first symptoms of Covid-19. Patients were divided into three groups: mild, moderate and severe group. Kidney injury was evaluated by markers including estimated glomerular filtration rate(eGFR), serum creatinine and blood urea nitrogen. Results: A total of 71 patients with 22 mild, 39 moderate and 10 severe COVID-19 were included in this study. During hospitalization, the level of creatinine was increased in 41% and blood urea nitrogen was increased in 15% of patients. Also, eGFR was decreased in 57% of patients. The average variable of eGFR was 46,7 mL/min/1,73m2. The kidney injury markers, including eGFR, serum creatinine and blood urea nitrogen all worsened with an increase in disease severity. Acute kidney injury was not demonstrated in either of the patients age groups. Conclusion: Worsened eGFR, serum creatinine and blood urea nitrogen levels in patients, who have never been diagnosed with kidney disease before and have Covid-19 symptoms for more than 24 hours, show that altered kidney function is associated with SARS-CoV-2. Although, it is necessary to determine new biomarkers of kidney injury in COVID-19 patients to establish an optimal treatment strategy.
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