THE STUDY OF ELECTROCHEMICAL PROPERTIES OF SOME PSYCHOACTIVE DRUGS

Abstract

Mental health is one of the most important factors for integrating a person into society, although along with this statement exists an opposite concept to this term - “mental disorder”. Because of a mental disorder, a person is unable to cope with problems and be adapted to given living conditions. The current approach to the treatment of mental disorders involves the use of psychotropic drugs, and at the same time, social and psychological intervention is important. The aim of our research was to study the electrochemical properties and select the optimal conditions for analysis of the psychoactive duloxetine, which is very interesting agent from toxicological point of view. In the patient information leaflet, you can directly find that the drug should be given to a patient under supervision of family member. The reason for such supervision is suicide ideas - the adverse reaction, provoked by this drug. Based on the conducted research, it was determined that duloxetine hydrochloride is the polarographically active substance, in aquatic and ethanoic solutions, under the conditions when background solution is 0.5 M NaClO4. Duloxetine gives single-wave diffuse curves in both solvents. Unlike duloxetine, diphenhydramine is not electrochemically active in aqueous and/or ethanoic solution of sodium perchlorate; however, it gives a polarographic wave in the following ratio of a 0.5 M NaClO₄ aquatic solution and Brighton-Robinson buffer volume (1: 1 (v/v)). Determined the frames of concentration ranges, in which the process is linear, for duloxetine (c = 1.12 · 10-4 - 8.4 · 10-4 mol / L (in water) and c = 6.54 · 10-4 - 7.19 10-3 mol /L (in ethanol)). In addition, was detected that, it is possible to use aquatic and alcoholic solutions for the quantitative determination of duloxetine hydrochloride, whereas the process is linear in both areas. The linearity  of the calibration curve in the aquatic area of 0.5 M NaClO4  solution is R2 = 0.9926, and in the alcoholic area - R2 = 0.971. The water solutions have high linearity and can be effectively used in quantitative determination of Duloxetine.