DIAGNOSTIC VALUE OF MULTINUCLEAR MACROPHAGES DETECTION IN BRONCHIAL LAVAGE FLUID OF THE PATIENT WITH AFB NEGATIVE TUBERCULOSIS
Cytological features of 273 patients’ bronchial lavage fluid was studied. These data was compared to the bacteriological test results. Predictor of Tuberculosis (TB) – multinuclear macrophages – was found in 55 cases (20.1%). Active TB was bacteriologically confirmed in 24 out of these 55 cases. Among the rest 218 macrophage negative cases active TB bacteriologically was confirmed only in 12 cases. The specificity and sensitivity of the test was 87% and 67% retrospectively. The results were clinically significant (84.2%). Kappa was 0.61. The detection of multinuclear macrophages reflects cellular alteration and precedes the allocation of Mycobacterium Tuberculosis. This process along with the clinical characteristics can be considered as the confirmation of active Tuberculosis.
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