MICROCIRCULATION CHANGES IN CRUSH SYNDROME
By using classical method of crush syndrome modeling, experiments were carried out on randomly chosen 50 white rats (200-250 gr)with various degrees of crush syndrome in compression and decompression periods. Microhemocirculation and microvascular adrenoreactivity was investigated in rats’ small intestine mesenteric arterioles by biomicroscope “Nikkon Labopot”. Microvascular adrenoreactivity was studied by means of pharmacological analysis, specifically with the use of epinephrine on the basis of a- and b- adrenal re- ceptor blockers action. The study results revealed, that crush syndrome leads to microhemocirculation disturbances in mesenteric arterioles. It is obvious due to numerous changes in microhemocirculation, microvessels diameter, blood flow linear speed, adrenoreactive structures dysfunction. The severity of the changes correlates with compression and especially with decompression period duration and is directly related to a– and b- receptors dysfunction.
2. Hamza SM1, Kaufman S. Splenic neurohormonal modulation of mesenteric vascular tone. Exp Physiol. 2012 Sep;97(9):1054-64. doi: 10.1113/expphysiol.2011.061010. Epub 2011 Dec 23.
3. Nagaraja AS, Sadaoui NC, Dorniak PL, Lutgendorf SK, Sood AK. SnapShot: Stress and DiseaseCell Metab. 2016 Feb 9;23(2):388-388.e1. doi: 10.1016/ j.cmet.2016.01.015
4. Nissar Shaikh. Common complication of crush injury, but a rare compartment syndrome. J Emerg Trauma Shock. 2010 Apr-Jun; 3(2): 177–181.
5. Pakdeechote P, Rummery NM, Ralevic V, Dunn WR. Raised tone reveals purinergic-mediated responses to sympathetic nerve stimulation in the rat perfused mesenteric vascular bed. Eur J Pharmacol. 2007 Jun 1;563(1-3):180-6. Epub 2007 Feb 17.
6. Rajagopalan S. Crush injuries and the crush syndrome. MJAFI 2010; 66: 317-20.
7. Sahjian, Michael, Frakes, Michael Crush Injuries: Pathophysiology and Current Treatment Advanced Emergency Nursing Journal June 2007, Volume :29 Number 2, page 145- 150.
8. Vanhoutte PM, Shimokawa H, Feletou M, Tang EH, Endothelial Dysfunction and Vascular Disease - A Thirthieth Anniversary Update. Acta Physiol (Oxf). 2015 Dec 26. doi:10.1111/apha.12646.