Retrospective analysis of patients’ operative material during reproductive period with leiomyoma

Retrospective analysis of patients’ operative material during reproductive period with leiomyoma

Authors

  • Mindia Iobashvili
  • Irma Jikia
  • Tamar Gogia
  • Lali Bekauri
  • Maka Jorbenadze
  • Marina Failodze

DOI:

https://doi.org/10.52340/spectri.2022.23

Abstract

Leiomyoma is known to be a benign tumor of unknown etiology of the uterus. It is most common in women of reproductive age with a cumulative frequency of 5.4% to 77.0%, and 80.0% of them suffer from this problem throughout their lives. However, some authors question the binding role of estrogen-progesterone in the growth of leiomyoma. However, due to the ineffectiveness of conservative treatment of leiomyoma, surgical intervention is still an effective method of curing the patient. There are no means of complete regression and prevention of this pathology. The aim of our study was retrospective analysis of operative material of patients of reproductive period with leukemia of the uterine body. Patients in both groups were divided into 40-year-olds and 41-50-year-olds according to age. The obtained results were processed using SPSS-21 software package of mathematical statistics. Pearson x2 criterion was used to test the reliability.Comparison of retrospective analysis of archival material revealed:

  1. A sharp increase in the incidence of intramural leiomyoma of the uterine body, due to many factors: social, ecological, stressful conditions, the introduction of modern diagnostic methods in practice.
  2. Proliferative, recurrent and latent leiomyomas are characterized by histostructural features.
  3. The process of growth of leiomyoma nodes is determined by the active products of the extracellular matrix, which leads to an increase in their size and does not depend on the histostructure, localization, number and size of the nodes
  4. Extracellular matrix products are important not only in terms of leiomyoma growth, but it is also likely to be among the factors that limit the free uncontrolled spread of tumor proliferation in the uterine body muscle and inhibit the assimilation process. This is confirmed by the absence of malignancy.
  5. Retrospective analysis of the material provides the basis for the search for molecular mechanisms of leiomyoma development. The results obtained will be important for the selection of drug treatment in terms of inhibition of myocyte proliferative processes, expression of growth factors and activation of apoptosis.

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Author Biographies

Mindia Iobashvili

PhD student

Irma Jikia

Associate Professor

Tamar Gogia

Associate Professor

Lali Bekauri

Associate Professor

Maka Jorbenadze

Associate Professor

Marina Failodze

Professor

References

Zimmermann A, Bernuit D, Gerlinger C, Schaefers M, Geppert K. Prevalence, symptoms and management of uterine fibroids: an international internet-based survey of 21,746 women. BMC Womens Health. 2012 Mar 26;12:6.

Arjeh S, Darsareh F, Asl ZA, Azizi Kutenaei M. Effect of oral consumption of vitamin D on uterine fibroids: A randomized clinical trial. Complement Ther Clin Pract. 2020 May;39:101159.

Shaukat I, Yassin S, Paudel A, Höti N, Mustafa S. Unusual presentation of parasitic leiomyoma; a tale of twists and turns. J Community Hosp Intern Med Perspect. 2019 Apr 12;9(2):168-170. 4. Carol Ann Dixon (2020) Four women, for women: Caribbean diaspora artists reimag(in)ing the fine art canon, African and Black Diaspora: An International Journal, 13:2, 161-176.

Khunte R, Li M, Behr B, Zhao Q, Baker VL. Blastocyst formation rate for Asians versus Caucasians and within body mass index categories. J Assist Reprod Genet. 2020 Apr;37(4):933-943.

Marnach ML, Laughlin-Tommaso SK. Evaluation and Management of Abnormal Uterine Bleeding. Mayo Clin Proc. 2019 Feb;94(2):326-335

Qin H, Lin Z, Vásquez E, Luan X, Guo F, Xu L. High soy isoflavone or soy-based food intake during infancy and in adulthood is associated with an increased risk of uterine fibroids in premenopausal women: a meta-analysis. Nutr Res. 2019 Nov;71:30-42.

Łoziński T, Filipowska J, Gurynowicz G, Zgliczyńska M, Kluz T, Jędra R, Skowyra A, Ciebiera M. The effect of high-intensity focused ultrasound guided by magnetic resonance therapy on obstetrical outcomes in patients with uterine fibroids - experiences from the main Polish center and a review of current data. Int J Hyperthermia. 2019;36(1):582-590.

Gross KL, Morton CC. Genetics and the development of fibroids. Clin Obstet Gynecol. 2001 Jun;44(2):335-49.

Rubisz P, Ciebiera M, Hirnle L, Zgliczyńska M, Łoziński T, Dzięgiel P, Kobierzycki C. The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium. Int J Mol Sci. 2019 Mar 6;20(5):1136.

Łoziński T, Filipowska J, Ludwin A, Ciebiera M. The outcome of magnetic resonance-guided high-intensity ultrasound for clinically symptomatic submucosal uterine fibroid performed accidentally in very early pregnancy: a case report. Int J Hyperthermia

Corachán A, Ferrero H, Escrig J, Monleon J, Faus A, Cervelló I, Pellicer A. Long-term vitamin D treatment decreases human uterine leiomyoma size in a xenograft animal model. Fertil Steril. 2020 Jan;113(1):205-216.e4.

Samy A, Raslan AN, Talaat B, El Lithy A, El Sharkawy M, Sharaf MF, Hussein AH, Amin AH, Ibrahim AM, Elsherbiny WS, Soliman HH, Metwally AA. Perioperative nonhormonal pharmacological interventions for bleeding reduction during open and minimally invasive myomectomy: a systematic review and network meta-analysis. Fertil Steril. 2020 Jan;113(1):224-233.e6.

Irahara M, Maejima Y, Shinbo N, Yamauchi Y, Mizunuma H. Ulipristal acetate for Japanese women with symptomatic uterine fibroids: A double-blind, randomized, phase II dose-finding study. Reprod Med Biol. 2019 Oct 30;19(1):65-74.

Kurachi O, Matsuo H, Samoto T, Maruo T. Tumor necrosis factor-alpha expression in human uterine leiomyoma and its down-regulation by progesterone. J Clin Endocrinol Metab. 2001 May;86(5):2275-80.

de Guzman GS, Manalo EM. Myomatous erythrocytosis syndrome: A case series. Case Rep Womens Health. 2019 Aug 21;24:e00139.

Alexander AL, Strohl AE, Rieder S, Holl J, Barber EL. Examining Disparities in Route of Surgery and Postoperative Complications in Black Race and Hysterectomy. Obstet Gynecol. 2019 Jan;133(1):6-12.

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Published

2022-06-21

How to Cite

Mindia Iobashvili, Irma Jikia, Tamar Gogia, Lali Bekauri, Maka Jorbenadze, & Marina Failodze. (2022). Retrospective analysis of patients’ operative material during reproductive period with leiomyoma. Scientific Journal „Spectri“, 1. https://doi.org/10.52340/spectri.2022.23

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Section

MEDICINE
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