The role of vitamin D3 deficiency in the etiopathogenesis of autoimmune thyroid diseases
Vitamin D is now recognized not only for promoting bone health in children and adults, but also for other health benefits, including reducing the risk of chronic diseases such as autoimmune diseases, malignancies, and cardiovascular disease. The aim of our study is to investigate whether there is a correlation between autoimmune thyroid disease and vitamin D 3 deficiency in the population of Georgia. The study cohort included a total of 306 patients aged 18–65 years (mean age 37.6 ± 11.3 years) referred to the National Institute of Endocrinology from 2018 to 2019The cohort included 87 men (total 28.4%) and 219 women (total 71.6%). A retrospective selection of the study population was made based on patient history. The study protocol was approved by the Medical Ethics Committee of our institute (Protocol N 448) and informed consent was signed by all patients. Results: Compared to controls the study droup were characterized by significantly higher frequencies of following factors: hair loss, brittle nails, dizziness, general weakness, mood swings. Compared to controls the study group were characterized by significantly higher frequencies of Anti-TPO (236.44+44 vs 0.409.65+84.22, p<0.0001). The mean value of vitamin D and TSh are unsatisfactory higher in the study group(6.1+8.64 vs 5.6+9.20, p=0.5161).
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