საკვანძო სიტყვები
ეპინეფრინი
გულ-სისხლძარღვთა სისტემა
ადგილობრივი ანესთეტიკები
ჰემოდინამიკა
ჰიპერტენზია
მიოკარდიუმის ინფარქტი
როგორ უნდა ციტირება
ანოტაცია
ვაზოკონსტრიქტორები ფართოდ გამოიყენება სამედიცინო და სტომატოლოგიურ პრაქტიკაში, განსაკუთრებით ადგილობრივ საანესთეზიო საშუალებებში, წამლების ეფექტურობის გასახანგრძლივებლად და სისტემური აბსორბციის შესამცირებლად. მიუხედავად იმისა, რომ ვაზოკონსტრიქტორები ზოგადად უსაფრთხოდ ითვლება, გაჩნდა შეშფოთება გულ-სისხლძარღვთა სისტემაზე მათი ზემოქმედების შესახებ, განსაკუთრებით პაციენტებში, რომლებსაც აქვთ გულის დაავადება. სამეცნიერო ნაშრომი იკვლევს ვაზოკონსტრიქტორების როლს, მათ ფარმაკოლოგიურ მექანიზმებს და მათ პოტენციურ რისკებსა და სარგებელს კლინიკურ გარემოში. თანამედროვე ლიტერატურისა და კლინიკური გაიდლაინების მიმოხილვით, ჩამოყალიბდა დასკვნები და რეკომენდაციები ვაზოკონსტრიქტორების უსაფრთხო გამოყენების შესახებ გულ-სისხლძარღვთა რისკის მქონე პაციენტებში. ვაზოკონსტრიქტორები არის ნივთიერებები, რომლებიც იწვევენ სისხლძარღვების შევიწროებას, რაც იწვევს სისხლძარღვთა წინააღმდეგობის და არტერიული წნევის მატებას. სტატია მიმოიხილავს მეცნიერულ დისკურსს ფიზიოლოგიურ მექანიზმებთან დაკავშირებით, რომლითაც ვაზოკონსტრიქტორები ახდენენ თავიანთ ზემოქმედებას გულ-სისხლძარღვთა სისტემაზე, ხაზგასმულია მათ როლზე გულის მუშაობის, მიოკარდიუმის ჟანგბადზე მოთხოვნილების და გულის საერთო ფუნქციის რეგულირებაში. სტატია განიხილავს ამ პროცესში ჩართულ მოლეკულურ გზებს, როგორიცაა ადრენერგული რეცეპტორების გააქტიურება, რენინ-ანგიოტენზინ-ალდოსტერონის სისტემა და ენდოთელინი, ასევე მათი პოტენციური თერაპიული შედეგები და რისკები. ასევე განხილულია სხვადასხვა ვაზოკონსტრიქტორების, მათ შორის ბუნებრივი ნივთიერებებისა და სინთეზური აგენტების სხვადასხვა ეფექტები გულის ფუნქციონირებაზე, როგორც ნორმალურ, ისე პათოლოგიურ მდგომარეობაში.
წყაროები
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