FORMULATION AND TECHNOLOGY OF POLYESTER AMIDE-BASED NANOPARTICLES LOADED WITH EXTRACT ERYSIMUM
РЕЦЕПТУРА И ТЕХНОЛОГИЯ ПОЛУЧЕНИЯ НАНОЧАСТИЦ СОДЕРЖАЩИХ ЭКСТРАКТ ERYSIMUM CONTRACTUM SOMM. ETLEVIER НА ОСНОВЕ ПОЛИЭСТЕРАМИДА
Аннотация
The purpose of this study was to formulate polyester amide-based nanoparticles loaded with extract Erysimum contractum Somm. et Levier. The influence of the various biopharmaceutical factors such as type of organic solvent, type and concentration of surfactant were studied. Modified emulsification solvent evaporation method was used for preparation of nanoparticles. Nanoparticle size, size distribution and entrapment efficiency were determined. Non-ionic surfactants polyvinyl alcohol provided more stable nanoparticles. Water miscible organic solvent, acetone obtained 270-300 nm nanoparticles with improved size distribution. Entrapment efficiency was increased to 49%. Based on the performed experiments optimal formulation of nanoccomposite is suggested.
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