FORMULATION AND TECHNOLOGY OF POLYESTER AMIDE-BASED NANOPARTICLES LOADED WITH EXTRACT ERYSIMUM
РЕЦЕПТУРА И ТЕХНОЛОГИЯ ПОЛУЧЕНИЯ НАНОЧАСТИЦ СОДЕРЖАЩИХ ЭКСТРАКТ ERYSIMUM CONTRACTUM SOMM. ETLEVIER НА ОСНОВЕ ПОЛИЭСТЕРАМИДА
Abstract
The purpose of this study was to formulate polyester amide-based nanoparticles loaded with extract Erysimum contractum Somm. et Levier. The influence of the various biopharmaceutical factors such as type of organic solvent, type and concentration of surfactant were studied. Modified emulsification solvent evaporation method was used for preparation of nanoparticles. Nanoparticle size, size distribution and entrapment efficiency were determined. Non-ionic surfactants polyvinyl alcohol provided more stable nanoparticles. Water miscible organic solvent, acetone obtained 270-300 nm nanoparticles with improved size distribution. Entrapment efficiency was increased to 49%. Based on the performed experiments optimal formulation of nanoccomposite is suggested.
Downloads
References
S. A. A. Rizvi and A. M. Saleh, “Applications of nanoparticle systems in drug delivery technology,” Saudi Pharm. J., vol. 26, no. 1, pp. 64–70, 2018, doi: 10.1016/j.jsps.2017.10.012.
D. R. Khan, “The use of nanocarriers for drug delivery in cancer therapy,” J. Cancer Sci. Ther., vol. 2, no. 3, pp. 58–62, 2010, doi: 10.4172/1948-5956.1000024.
J. P. Rao and K. E. Geckeler, “Polymer nanoparticles: Preparation techniques and size-control parameters,” Prog. Polym. Sci., vol. 36, no. 7, pp. 887–913, 2011, doi:10.1016/ j.progpolymsci.2011.01.001.
S. L. Pal, U. Jana, P. K. Manna, G. P. Mohanta, and R. Manavalan, “Nanoparticle: An overview of preparation and characterization,” J. Appl. Pharm. Sci., vol. 1, no. 6, pp. 228–234, 2011.
A. Bakuridze, D. Beridze, M. Jokhadze, and M. Metreveli, “The Study of Ajara and Ajara-Lazica Endemics on the Content of Biologically Active Compound Coumarin,” no. 4, pp. 76–83, 2016.
Dali Beridze, Malkhaz Jokhadze, Aliosha Bakuridze, Mariam Metreveli, Zurab Manvelidze, “GAS CHROMATOGRAPHY-MASS SPECTROMETRY ( GC-MS ) ANALYSIS OF BIOACTIVE COMPOUNDS OF AJARA AND AJARA-LAZICA ENDEMIC SPECIES. International Journal of Current Research, Vol. 08, Issue, 09, pp. 38939-38944, September, 2016.
Y. Dang and J. Guan, “Nanoparticle-based drug delivery systems for cancer therapy,” Smart Mater. Med., vol. 1, no. February, pp. 10–19, 2020, doi: 10.1016/j.smaim.2020.04.001.
