RESVERATROL THE MAIN CONSTITUENT OF COSMETOLOGY AND DERMATOLOGICAL PRODUCTS: REVIEW

KETEVAN GULDEDAVA; NINO IMNADZE

doi:10.52340/jecm.2023.04.28

RESVERATROL THE MAIN CONSTITUENT OF COSMETOLOGY AND DERMATOLOGICAL PRODUCTS: REVIEW

Авторы

KETEVAN GULDEDAVA Tbilisi State Medical University
NINO IMNADZE Tbilisi State Medical University

DOI:

https://doi.org/10.52340/jecm.2023.04.28

Ключевые слова:

Resveratrol, dermatology, cosmetology, polyphenolic compound

Аннотация

Resveratrol is being widely used in dermatology and cosmetology these days. This polyphenolic compound is present in large amounts in red grapes and berries and has a number of scientifically proven beneficial effects on the human body. Those are: a positive effect on the cardiovascular system, lowering the concentration of low-density lipoprotein and the ability to inhibit the cyclooxygenases activity. Additionally, it has anti-proliferative, anti-angiogenic, anti-inflammatory, antioxidant and antimicrobial properties. Its popularity in cosmetology and dermatology is primarily associated with proven ability to easily penetrate the skin barrier and anti-aging activity. It has been shown that formulations with resveratrol can stimulate the proliferation of fibroblasts and contributing to the increase in the concentration of collagen III. Resveratrol has an affinity for the estrogen protein receptors, thereby contributing to the stimulation of collagen types I and II production. Moreover, resveratrol has also antioxidant properties, thus can protect cells against oxidative damage associated with the effects of free radicals and UV radiation on the skin and it slows down the process of photo-aging of the skin. The article reviews literature on the skin care properties of resveratrol and its dermal bioavailability, metabolism and safety of topical application.

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