THE ROLE OF MATERNAL AGE AND MEDICAL HISTORY IN THE RISK OF NON-DEVELOPING PREGNANCY

Аннотация

Non-developing pregnancy is a complex problem, risk factors, as well as causes, are not fully understood. Objective: to assess the relationship of non-developing pregnancy with maternal age and medical history. The study involved 123 pregnant women, of which 103 pregnant women with non-developing pregnancy for up to 12 weeks (main group) and 20 women in the same period of pregnancy without complications (control group). Data collection included: age of patients, severity of pregnancy, parity, history of previous pregnancy and childbirth. Among the women of the main group, two groups of women with different forms of non-developing pregnancy were distinguished: group I - 45.6% of women with non-developing pregnancy according to type I anembryony, group II - 54.4% of women - according to the type of embryonic death. The age of women ranged from 20 to 38 years. The average age of women in the main group was 31.01±2.85 years. In 35.0% of cases, women were aged 20-30 years, in 65.0% of cases - aged 31-38 years. The average age of patients in group I with anembryony was 30.14±4.82 years, in group II with embryonic death - 32.54±5.05 years, in the control group 25.6±2.15 years. In groups I, II and the control group, at the age of 20-30 there were 42.6%, 28.6% and 60.0% of women, and in the age group of 31-38 years - 57.4%, 71.4% and 40.0% of women, respectively. The probability of miscarriage development was significantly higher in the older age group (OR=0.292, 95% CI 0.163-0.512, p<0.05). There are significantly more primigravidas in group I than in group II (p=0.012), and there are significantly more recurrent pregnancies in group II (p=0.012). There was a high probability of term delivery in group I - OR=2.914 (95% CI 1.025-8.285, p<0.05). The probability of miscarriage (OR=0.841 95% CI 0.306-2.310, p>0.05), medical abortion (OR=0.568 95% CI 0.176-1.831, p>0.05) was high in group II. Women with a history of miscarriage and abortion should be more closely monitored and assisted with appropriate interventions in the first trimester or even before conception to achieve better clinical outcomes.