THE IMPACT OF EXPOSURE TO SMALL DOSES OF LEAD IN THE PRENATAL AND INTRANATAL PERIOD ON THE CHARACTERISTICS OF THE FETUS

NATO GORGADZE; JUMBER UNGIADZE; MANANA GIORGOBIANI; VERA BAZIARI; KHATUNA LOMAURI; DAVIT KOHELET

doi:10.52340/jecm.2023.03.19

THE IMPACT OF EXPOSURE TO SMALL DOSES OF LEAD IN THE PRENATAL AND INTRANATAL PERIOD ON THE CHARACTERISTICS OF THE FETUS

Авторы

NATO GORGADZE
JUMBER UNGIADZE
MANANA GIORGOBIANI
VERA BAZIARI
KHATUNA LOMAURI
DAVIT KOHELET

DOI:

https://doi.org/10.52340/jecm.2023.03.19

Ключевые слова:

fetus, placenta, newborn, lead, impact

Аннотация

Among the most dangerous substances that have a negative impact on the human body, lead occupies the second place. It has no physiological importance in the human body and therefore it can accumulate over time, causing harmful long-term effects. It is especially dangerous for pregnant women, since previously stored lead is released into the blood during pregnancy, and has the capacity to freely pass through the placental barrier and harm the fetus. We studied the level of lead exposure in the prenatal and intranatal period and its effect on the characteristics of the fetus, newborn and placenta. Our data revealed differences in relation to gestation and gender, as well as the levels of lead in the blood when the effect was maximal.

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Библиографические ссылки

Mitra, P., Sharma, S., Purohit, P., & Sharma, P. (2017). Clinical and molecular aspects of lead toxicity: An update. Critical reviews in clinical laboratory sciences, 54(7-8), 506-528.

Collin, M. S., kumar Venkataraman, S., Vijayakumar, N., Kanimozhi, V., Arbaaz, S. M., Stacey, R. S., & Swamiappan, S. (2022). Bioaccumulation of lead (Pb) and its effects on human: A review. Journal of Hazardous Materials Advances, 100094.

Halmo, L., & Nappe, T. M. (2019). Lead toxicity. PMID: 31082141.

Ara A, Usmani JA. Lead toxicity: a review. Interdisciplinary toxicology. 2015 Jun;8(2):55-6.

Gade, M., Comfort, N., & Re, D. B. (2021). Sex-specific neurotoxic effects of heavy metal pollutants: Epidemiological, experimental evidence and candidate mechanisms. Environmental research, 201, 111558.

Rísová, V. (2019). The pathway of lead through the mother’s body to the child. Interdiscipl Toxicology, 12(1):1-6.

Gilbert-Diamond, D., Emond, J. A., Baker, E. R., Korrick, S. A., & Karagas, M. R. (2016). Relation between in utero arsenic exposure and birth outcomes in a cohort of mothers and their newborns from New Hampshire. Environmental health perspectives, 124(8):1299-1307.

Signes-Pastor, A. J., Doherty, B. T., Romano, M. E., Gleason, K. M., Gui, J., Baker, E., & Karagas, M. R. (2019). Prenatal exposure to metal mixture and sex-specific birth outcomes in the New Hampshire Birth Cohort Study. Environ Epidemiol. 3(5): e068.

Ahmadi, S., Botton, J., Zoumenou, R., Ayotte, P., Fievet, N., Massougbodji, A., & Bodeau-Livinec, F. (2022). Lead exposure in infancy and subsequent growth in Beninese children. Toxics, 10(10):595.

Molina-Mesa, S., Martínez-Cendán, J. P., Moyano-Rubiales, D., Cubillas-Rodríguez, I., Molina-García, J., & González-Mesa, E. (2022). Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman. International Journal of Environmental Research and Public Health, 19(22):14731.

Hosseini G, Hanaie J, Ostadi A, Valipor J, Hamidi A, Ghanbarzadeh S. A Rapid Mercury Droplet Electrode Polarography Method for Determination of Blood Lead Level in Lead Poisoned People. Drug Research. 2021 Apr;71(04):193-8.

Ara A, Usmani JA. Lead toxicity: a review. Interdisciplinary toxicology. 2015 Jun;8(2):55-64.

https://www.atsdr.cdc.gov/spl/

Renzetti S, Just AC, Burris HH, Oken E, Amarasiriwardena C, Svensson K, Mercado-García A, Cantoral A, Schnaas L, Baccarelli AA, Wright RO. The association of lead exposure during pregnancy and childhood anthropometry in the Mexican PROGRESS cohort. Environmental research. 2017 Jan 1;152:226-32.

American Academy of Pediatrics. American academy of pediatrics committee on fetus and newborn, American college of obstetricians and gynecologists committee on obstetric practice. The Apgar Score. Pediatrics. 2015;136(4):819-22.

Razaz N, Cnattingius S, Joseph KS. Association between Apgar scores of 7 to 9 and neonatal mortality and morbidity: populationbased cohort study of term infants in Sweden. bmj. 2019 May 7;365.

Stojsavljević A, Perović M, Nešić A, Miković Ž, Manojlović D. Levels of non-essential trace metals and their impact on placental health: a review. Environmental Science and Pollution Research. 2022 Jun;29(29):43662-74.

Burris HH, Collins Jr JW, Wright RO. Racial/ethnic disparities in preterm birth: clues from environmental exposures. Current opinion in pediatrics. 2011 Apr;23(2):227.

Cantonwine D, Hu H, Téllez-Rojo MM, Sánchez BN, Lamadrid-Figueroa H, Ettinger AS, Mercado-García A, Hernández-Avila M, Wright RO. HFE gene variants modify the association between maternal lead burden and infant birthweight: a prospective birth cohort study in Mexico City, Mexico. Environmental Health. 2010 Dec; 9:1-9.

Gonzalez-Cossio T, Peterson KE, Sanin LH, Fishbein E, Palazuelos E, Aro A. Decrease in birth weight in relation to maternal bone-lead burden. Pediatr 100: 856-62.

Zhang B, Xia W, Li Y, Bassig BA, Zhou A, Wang Y, Li Z, Yao Y, Hu J, Du X, Zhou Y. Prenatal exposure to lead in relation to risk of preterm low birth weight: A matched case–control study in China. Reproductive Toxicology. 2015 Nov 1; 57:190-5.

Abadin H, Ashizawa A, Llados F, Stevens YW. Toxicological profile for lead. 2007. PMID: 24049859.

Gleason KM, Valeri L, Shankar AH, Hasan MO, Quamruzzaman Q, Rodrigues EG, Christiani DC, Wright RO, Bellinger DC, Mazumdar M. Stunting is associated with blood lead concentration among Bangladeshi children aged 2-3 years. Environmental Health. 2016 Dec;15(1):1-9.

Silbergeld EK. Lead in bone: implications for toxicology during pregnancy and lactation. Environmental health perspectives. 1991 Feb;91:63-70.

Davis, M. A., Li, Z., Gilbert-Diamond, D., Mackenzie, T. A., Cottingham, K. L., Jackson, B. P.,... & Karagas, M. R. (2014). Infant toenails as a biomarker of in utero arsenic exposure. Journal of exposure science & environmental epidemiology, 24(5), 467-473.

Levander OA. Lead toxicity and nutritional deficiencies. Environmental health perspectives. 1979 Apr;29:115-25.

Papanikolaou NC, Hatzidaki EG, Belivanis S, Tzanakakis GN, Tsatsakis AM. Lead toxicity update. A brief review. Medical science monitor. 2005 Oct 1;11(10):RA329.

Vorvolakos, T., Arseniou, S., & Samakouri, M. (2016). There is no safe threshold for lead exposure: Α literature review. Psychiatriki, 27(3), 204-214.