BACTERIOPHAGE – ALTERNATIVE TO ANTIBIOTICS?
DOI:
https://doi.org/10.52340/jecm.2023.02.11Ключевые слова:
Bacteriophage, antibiotics, antimicrobial therapyАннотация
The emergence of antimicrobial resistance and increase in side effects of antibiotic therapy is actual problem in pediatrics. Bacteriophages are one of the most promising alternatives to antibiotics for clinical use. The aim of the work was to define the therapy effect of phages administered per os in children with diarrheal diseases. An open observation controlled clinical trial was performed. 52 children aged from 3 to 15 years with diarrheal diseases of bacterial etiology were monitored, as outpatients. According to our clinical trial results (preliminary results) Bacteriophage therapy with SEPTAPHAGE improves clinical course of diarrhea in outpatients aged from 3 to 15 years. Thus, Bacteriophage therapy seems to be effective and safe antimicrobial therapy.
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Aminov, R.; Caplin, J.; Chanishvili, N.; Coffey, A.; Cooper, I.; De Vos, D.; Doškar, J.; Friman, V.; Kurtböke, I.; Pantucek, R.; et al. Application of bacteriophages. Microbiol. Aust. 2018, 38, 63–66.
Kaitlyn E. Kortright et al. Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria. Cell host and Microbe. Volume 25, Issue 2, 13 February 2019, Pages 219-232
Milton W. Taylor. The Discovery of Bacteriophage and the d’Herelle Controversy. Viruses and Man: A History of Interactions. P. 53-61. 2014 Springer.
Vijay et al. An Early History of Phage Therapy in the United States: Is it Time to Reconsider? Clin Med Res. 2021 Jun; 19(2): 82–89.
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