SUBCUTANEOUS FAT NECROSIS OF THE NEWBORN: CLINICAL CASE

SUBCUTANEOUS FAT NECROSIS OF THE NEWBORN: CLINICAL CASE

Authors

  • TINATIN KUTUBIDZE Tbilisi State Medical University
  • NINELI CHKHAIDZE
  • EKA NAKHUTSRISHVILI

DOI:

https://doi.org/10.52340/jecm.2022.08.02

Keywords:

SCFN, neonate, panniculitis

Abstract

A rare case of SCFN was diagnosed in a newborn, a rare disease in the neonatal period, emphasizes the importance of a histological findings for a definitive diagnosis. Subcutaneous fat necrosis of the newborn (SCFN) is an uncommon panniculitis of neonates. Although SCFN is a self-limited condition, recognition of this entity is important, as affected infants require monitoring for associated hypercalcemia or other complications. SCFN generally has a good outcome, with spontaneous resolution of skin lesions over weeks to months. However, death from hypercalcemia has been reported in a few infants with SCFN.

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References

Hicks MJ, Levy ML, Alexander J, Flaitz CM. Subcutaneous fat necrosis of the newborn and hypercalcemia: case report and review of the literature. Pediatr Dermatol 1993; 10:271.

Del Pozzo-Magaña BR, Ho N. Subcutaneous Fat Necrosis of the Newborn: A 20-Year Retrospective Study. Pediatr Dermatol 2016; 33:e353.

Hogeling M, Meddles K, Berk DR, et al. Extensive subcutaneous fat necrosis of the newborn associated with therapeutic hypothermia. Pediatr Dermatol 2012; 29:59.

Subcutaneous Fat Necrosis of the Newborn, Sungat K Grewal; Chief Editor: William D James, MD, Updated: May 15, 2018

Mitra S, Dove J, Somisetty SK. Subcutaneous fat necrosis in newborn-an unusual case and review of literature. Eur J Pediatr 2011; 170:1107.

Inherited Immunodeficiency: A New Association With Early Onset Childhood Panniculitis, Brigitte Bader-Meunier, MD, PEDIATRICS Volume 141, number s5, April 2018

Farooque A, Moss C, Zehnder D, et al. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in subcutaneous fat necrosis. Br J Dermatol 2009; 160:423.

Kruse K, Irle U, Uhlig R. Elevated 1,25-dihydroxyvitamin D serum concentrations in infants with subcutaneous fat necrosis. J Pediatr 1993; 122:460.

Cook JS, Stone MS, Hansen JR. Hypercalcemia in association with subcutaneous fat necrosis of the newborn: studies of calcium-regulating hormones. Pediatrics 1992; 90:93.

Sharata H, Postellon DC, Hashimoto K. Subcutaneous fat necrosis, hypercalcemia, and prostaglandin E. Pediatr Dermatol 1995; 12:43.

Metz SA, Hassal E. PGE, hypercalcemia, and subcutaneous fat necrosis. J Pediatr 1980; 97:336.

Stefanko NS, Drolet BA. Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature. Pediatr Dermatol 2019; 36:24.

Xu Z, Rubin AI, Oboite M. Subcutaneous fat necrosis of the newborn presenting as circular alopecia: a novel presentation. Pediatr Dermatol 2021; 38:982.

Mahé E, Girszyn N, Hadj-Rabia S, et al. Subcutaneous fat necrosis of the newborn: a systematic evaluation of risk factors, clinical manifestations, complications and outcome of 16 children. Br J Dermatol 2007; 156:709.

Shumer DE, Thaker V, Taylor GA, Wassner AJ. Severe hypercalcaemia due to subcutaneous fat necrosis: presentation, management and complications. Arch Dis Child Fetal Neonatal Ed 2014; 99:F419.

Canpolat N, Özdil M, Kuruğoğlu S, et al. Nephrocalcinosis as a complication of subcutaneous fat necrosis of the newborn. Turk J Pediatr 2012; 54:667.

Chrysaidou K, Sargiotis G, Karava V, et al. Subcutaneous Fat Necrosis and Hypercalcemia with Nephrocalcinosis in Infancy: Case Report and Review of the Literature. Children (Basel) 2021;8.

Nair S, Nair SG, Borade A, Ramakrishnan K. Hypercalcemia and metastatic calcification in a neonate with subcutaneous fat necrosis. Indian J Pediatr 2009; 76:1155.

Borgia F, De Pasquale L, Cacace C, et al. Subcutaneous fat necrosis of the newborn: be aware of hypercalcaemia. J Paediatr Child Health 2006; 42:316.

Tran JT, Sheth AP. Complications of subcutaneous fat necrosis of the newborn: a case report and review of the literature. Pediatr Dermatol 2003; 20:257.

Sahni M, Patel P, Muthukumar A. Severe Thrombocytosis in a Newborn with Subcutaneous Fat Necrosis and Maternal Chorioamnionitis. Case Rep Hematol 2020; 2020:5742394.

Beuzeboc Gérard M, Aillet S, Bertheuil N, et al. Surgical management of subcutaneous fat necrosis of the newborn required due to a lack of improvement: a very rare case. Br J Dermatol 2014; 171:183.

Thomas JM, Bhandari J, Rytina E, et al. Subcutaneous Fat Necrosis of the Neonate with a Delayed Second Eruption. Pediatr Dermatol 2016; 33:e134.

Elsayed EOS, Yusuf K, Fraulin FOG, Murthy P. Haematoma complicating subcutaneous fat necrosis of the newborn: a rare complication following therapeutic hypothermia. BMJ Case Rep 2020; 13.

Schubert PT, Razak R, Jordaan HF. Fine-Needle Aspiration as a Method of Diagnosis of Subcutaneous Fat Necrosis of the Newborn. Pediatr Dermatol 2016; 33:e220.

Schubert PT, Razack R, Vermaak A, Jordaan HF. Fine-needle aspiration cytology of subcutaneous fat necrosis of the newborn: the cytology spectrum with review of the literature. Diagn Cytopathol 2012; 40:245.

Vasireddy S, Long SD, Sacheti B, Mayforth RD. MRI and US findings of subcutaneous fat necrosis of the newborn. Pediatr Radiol 2009; 39:73.

Weedon D. Panniculitis. In: Weedon's Skin Pathology, 3rd ed, Weedon D (Ed), Churchill Livingstone/Elsevier, 2010. p.1041.

Rapini RP. Practical Dermatopathology, Elsevier Mosby, 2005.

Zeb A, Darmstadt GL. Sclerema neonatorum: a review of nomenclature, clinical presentation, histological features, differential diagnoses and management. J Perinatol 2008; 28:453.

Akın MA, Akın L, Sarıcı D, et al. Follow-up during early infancy of newborns diagnosed with subcutaneous fat necrosis. J Clin Res Pediatr Endocrinol 2011; 3:216.

Chesover AD, Harrington J, Mahmud FH. Pamidronate as first-line treatment of hypercalcemia in neonatal subcutaneous fat necrosis: A case series. Paediatr Child Health 2021; 26:e52.

Schofield R, McMaster D, Cotterill A, Musthaffa Y. Lessons learnt in the management of hypercalcaemia secondary to subcutaneous fat necrosis of the newborn. J Paediatr Child Health 2021; 57:947.

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Published

2022-12-07

How to Cite

KUTUBIDZE, T., CHKHAIDZE, N., & NAKHUTSRISHVILI, E. (2022). SUBCUTANEOUS FAT NECROSIS OF THE NEWBORN: CLINICAL CASE. Experimental and Clinical Medicine Georgia, (8). https://doi.org/10.52340/jecm.2022.08.02

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