ASSOCIATION BETWEEN HASHIMOTO’S THYROIDITIS AND DEPRESSION

MARIAM GIGILASHVILI; GURAM MATITASHVILI; RATI RAMISHVILI

doi:10.52340/jecm.2022.02.04

ASSOCIATION BETWEEN HASHIMOTO’S THYROIDITIS AND DEPRESSION

Authors

MARIAM GIGILASHVILI
GURAM MATITASHVILI
RATI RAMISHVILI

DOI:

https://doi.org/10.52340/jecm.2022.02.04

Abstract

Hashimoto’s thyroiditis is a disease of the thyroid gland which affects the body in various ways leading to somatic complications. In addition to that, it affects the patient’s mental health. The extent of psychiatric diseases in patients with Hashimoto’s thyroiditis is not extensively explored. The primary objective of this study was to find the association between Hashimoto’s disease and depression in female patients aged 36-50 from North America/Central America. Questionnaires were designed to assess the extent of possible depression in those patients. We compared 115 cases to 188 controls. After analyzing results, we found that relative risk for developing depression in patients with hashimoto’s disease was 1.7202 (95% CI 1.4722- 2.0099, p value< 0.001). Thus, we concluded that Hashimoto’s disease is associated with increased risk of development of depression in a given sample.

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Author Biographies

MARIAM GIGILASHVILI

USMD Program, Tbilisi State Medical University, Tbilisi Georgia

GURAM MATITASHVILI

USMD Program, Tbilisi State Medical University, Tbilisi Georgia

RATI RAMISHVILI

USMD Program, Tbilisi State Medical University, Tbilisi Georgia

References

Siegmann EM, Müller HHO, Luecke C, Philipsen A, Kornhuber J, Grömer TW. Association of Depression and Anxiety Disorders with Autoimmune Thyroiditis: A Systematic Review and Meta-analysis. JAMA Psychiatry 2018;75(6):577-84.

Hashimoto H. Zur Kenntniss der lymphomatösen Veränderung der Schilddrüse (Struma lymphomatosa). Arch Klin Chir 1912; 97:219–48

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018;392(10159):1789-1858.

McCarter T. Depression overview. Am Health Drug Benefits 2008;1(3):44-51.

Shim RS, Baltrus P, Ye J, Rust G. Prevalence, treatment, and control of depressive symptoms in the United States: results from the National Health and Nutrition Examination Survey (NHANES), 2005-2008. J Am Board Fam Med 2011;24(1):33-38.

Chueire VB, Romaldini JH, Ward LS. Subclinical hypothyroidism increases the risk for depression in the elderly. Arch Gerontol Geriatr 2007;44(1):21-28.

Engum A, Bjøro T, Mykletun A, Dahl AA. An association between depression, anxiety and thyroid function--a clinical fact or an artefact? Acta Psychiatr Scand 2002;106(1):27-34.

Kim JS, Zhang Y, Chang Y, et al. Subclinical Hypothyroidism and Incident Depression in Young and Middle-Age Adults. J Clin Endocrinol Metab2018;103(5):1827-33.

Chueire VB, Silva ET, Perrotta E, Romaldini JH, Ward LS. High serum TSH levels are associated with depression in the elderly. Arch Gerontol Geriatr 2003;36(3):281-88.

Marangell LB, Callahan AM. Mood disorders and the thyroid axis. Curr Opin Psychiatry 1998;11(1):67-70.

Hendrick V, Altshuler L, Whybrow P. Psychoneuroendocrinology of mood disorders. The hypothalamic-pituitary-thyroid axis. Psychiatr Clin North Am 1998;21(2):277-92.

Toulis KA, Anastasilakis AD, Tzellos TG, Goulis DG, Kouvelas D. Selenium supplementation in the treatment of Hashimoto's thyroiditis: a systematic review and a meta-analysis. Thyroid 2010;20(10):1163-73.