It is commonly believed that childhood trauma can manifest into mood disorders in adulthood; the aim of our study is to thoroughly review the array of mood disorders that can be caused by childhood trauma and underline the predisposing risk factors and mechanisms of developing negative symptoms. We are trying to investigate the relationship between specific trauma types and mood disorders. For this purpose, we reviewed more than 20 articles on various childhood traumas, mood disorders, their mechanisms, and relationship. In our research, we specifically focus on the risk of developing mood disorders in the victims of physical abuse, sexual abuse, and neglect, briefly review the statistical data, as well as try to explain the pathophysiologic mechanism by analyzing: genetic factors, neuroplasticity, HPA axis, hippocampal volume and the effect of oxytocin.


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