EFFECTS OF NICOTINE ON GLUTAMAT-GLUTAMINE CYCLE AND PURINE METABOLISM IN A MOUSE MODEL OF PARKINSON’S DISEASE
DOI:
https://doi.org/10.52340/jecm.2025.06.19Keywords:
Effects, nicotine, glutamate-glutamine, cycle, purine, mouse model, Parkinson's diseaseAbstract
Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons and metabolic imbalances. This study aimed to determine whether nicotine modulates MPTP-induced parkinsonism in mice. BALB/c mice were divided into four groups: control, nicotine-only, MPTP-treated, and MPTP+nicotine. Analysis of substantia nigra tissue revealed that MPTP caused dopaminergic deficits and disrupted glutamate and purine metabolism, while nicotine treatment normalized these alterations. In conclusion, nicotine exhibits a protective effect against glutamate and purine metabolic disturbances associated with Parkinson's disease.
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