SEX DIFFERENCIES IN PATIENTS WITH GASTRIC CANCER IN GEORGIA, 2015-2022

SEX DIFFERENCIES IN PATIENTS WITH GASTRIC CANCER IN GEORGIA, 2015-2022

Authors

  • SABA ZHIZHILASHVILI Tbilisi State Medical University image/svg+xml
  • NANA MEBONIA National Center for Disease Control and Public Health, Georgia
  • IRAKLI MCHEDLISHVILI Tbilisi State Medical University image/svg+xml
  • ANA ZHIZHILASHVILI Tbilisi State Medical University image/svg+xml
  • TINATIN GABRICHIDZE Tbilisi State Medical University image/svg+xml

DOI:

https://doi.org/10.52340/jecm.2025.06.17

Keywords:

Gastric Cancer, Sex Differences, Georgia

Abstract

The study aimed to estimate the sex-specific characteristics of invasive gastric cancer morbidity and mortality in patients diagnosed in Georgia between 2015 and 2022. We conducted cancer population registry-based study. Between 2015 and 2022, the age-standardized incidence rate (ASIR) of gastric cancer in Georgia decreased from 12.0 to 11.5 in men and from 5.9 to 4.3 in women. However, across all calendar years included in the analysis, ASIR was approximately twice as high in men as in women. During this period, the age-standardized mortality rate decreased from 10.5 to 7.3 in men and from 5.8 to 3.0 in women. No trend of stable reduction in morbidity and mortality was observed throughout the observation period. The univariate Cox regression analysis confirmed that men diagnosed with gastric cancer have a slightly higher risk of mortality than women, although multivariate analysis did not confirm that patient gender is an independent determinant of mortality. During planning preventive activities for gastric cancer, the disease gender characteristics should be considered.

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References

Arnold M, Abnet CC, Neale RE, Vignat J, Giovannucci EL, McGlynn KA, Bray F. Global Burden of 5 Major Types of Gastrointestinal Cancer. Gastroenterology. 2020 Jul;159(1):335-349.e15. doi: 10.1053/j.gastro.2020.02.068

Grad C, Grad S, Fărcaş RA, Popa S, Dumitraşcu DL. Changing trends in the epidemiology of gastric cancer. Med Pharm Rep. 2023 Jul;96(3):229-234. doi: 10.15386/mpr-2538

Ilic M, Ilic I. Epidemiology of stomach cancer. World J Gastroenterol. 2022 Mar 28;28(12):1187-1203. doi: 10.3748/wjg.v28.i12.1187

Kilian C, Neufeld M, Manthey J et al. Self-reported changes in alcohol and tobacco use during COVID-19: findings from the eastern part of WHO European Region. Eur J Public Health. 2022 Jun 1;32(3):474-480. doi: 10.1093/eurpub/ckac011. PMID: 35137046; PMCID: PMC9159328.

Li H, Wei Z, Wang C, Chen W, He Y, Zhang C. Gender Differences in Gastric Cancer Survival: 99,922 Cases Based on the SEER Database. J Gastrointest Surg. 2020 Aug;24(8):1747-1757. doi: 10.1007/s11605-019-04304-y. Epub 2019 Jul 25. PMID: 31346960.

Li WY, Han Y, Xu HM, Wang ZN, Xu YY, Song YX, Xu H, Yin SC, Liu XY, Miao ZF. Smoking status and subsequent gastric cancer risk in men compared with women: a meta-analysis of prospective observational studies. BMC Cancer 2019; 19: 377. PMID: 31014273 DOI: 10.1186/s12885-019-5601-9.

Milano AF. 20-Year Comparative Survival and Mortality of Cancer of the Stomach by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period, Disease Duration & Selected ICD-O-3 Oncologic Phenotypes: A Systematic Review of 157,258 Cases for Diagnosis Years 1973-2014: (SEER*Stat 8.3.4). J Insur Med. 2019; 48 (1): 5-23. doi: 10.17849/insm-48-1-1-19.1

Morgan E, Arnold M, Camargo MC, et al. The current and future incidence and mortality of gastric cancer in 185 countries, 2020-40: A population-based modeling study. EClinicalMedicine. 2022 Apr 21;47:101404. doi: 10.1016/j.eclinm.2022.101404

Shin WS, Xie F, Chen B, Yu P, Yu J, To KF, Kang W. Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge. Cancers (Basel). 2023 May 6;15(9):2639. doi: 10.3390/cancers15092639

Song Y, Liu X, Cheng W, Li H, Zhang D. The global, regional, and national burden of stomach cancer and its attributable risk factors from 1990 to 2019. Sci Rep.2022 Jul7;12(1):11542. doi: 10.1038/s41598-022-15839-7

Theilmann M, Lemp JM, Winkler V et al. Patterns of tobacco use in low and middle-income countries by tobacco product and sociodemographic characteristics: nationally representative survey data from 82 countries. BMJ. 2022 Aug 30;378: e067582. doi: 10.1136/bmj-2021-067582. PMID: 36041745.

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Published

2025-12-05

How to Cite

ZHIZHILASHVILI, S., MEBONIA, N., MCHEDLISHVILI, I., ZHIZHILASHVILI, A., & GABRICHIDZE, T. (2025). SEX DIFFERENCIES IN PATIENTS WITH GASTRIC CANCER IN GEORGIA, 2015-2022. Experimental and Clinical Medicine Georgia, (6), 113–116. https://doi.org/10.52340/jecm.2025.06.17

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