SERUM ALDOSTERONE AND PLASMA RENIN ACTIVITY PROFILES IN DIAGNOSING SALT SENSITIVITY IN METABOLIC SYNDROME

IRINE ANDRONIKASHVILI; ALEXANDRE TAVARTKILADZE; DIANA LABARTKAVA; SOPHIE TATISHVILI; NATO PANTSULAIA

doi:10.52340/jecm.2025.05.13

SERUM ALDOSTERONE AND PLASMA RENIN ACTIVITY PROFILES IN DIAGNOSING SALT SENSITIVITY IN METABOLIC SYNDROME

Authors

IRINE ANDRONIKASHVILI
ALEXANDRE TAVARTKILADZE
DIANA LABARTKAVA
SOPHIE TATISHVILI
NATO PANTSULAIA

DOI:

https://doi.org/10.52340/jecm.2025.05.13

Keywords:

Salt sensitivity, Metabolic syndrome, Aldosterone, Plasma renin, Hypertension, ARR

Abstract

Background: Salt sensitivity (SS) is a major contributor to hypertension in the context of Metabolic Syndrome (MetS). This study evaluated serum aldosterone and plasma renin activity (PRA) as diagnostic tests for SS in the clinical context of MetS.

Methods: 120 met individuals with MetS participated in a dietary sodium protocol. Blood pressure (BP), serum aldosterone, and PRA were conducted in the high- and low-sodium phases of the study. Salt Sensitivity was defined as a increase in MAP of ≥10 mmHg. An aldosterone-renin ratio (ARR) was considered.

Results: 39.2% of participants were salt sensitive. The SS group had lower PRA and higher aldosterone levels relative to baseline during the high sodium condition. ARR held a high degree of predictive value of SS (AUC 0.87).

Conclusions: Aldosterone and PRA response to dietary sodium challenge identify SS phenotype of MetS and are helpful for complexities of precision care.

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