POSSIBILITY OF CANCER INDUCTION IN CASE OF ALLOTRANSPLANTATIONS
Abstract
In some cases of allotransplantation, simultaneous development of malignant tumors of different histogenesis and localization may be observed. We propose to consider malignant tumor formation during allotransplantations in terms of karyogamic theory of carcinogenesis. Experience in transplantology tentatively testify than even in causes of maximal antigen compatibility of donors and recipients, immune conflict between them is unavoidable. As we believe, in immunological conflict between recipient and donor cells, the process of cells’ destruction in some cases may be accompanied by damages (perforations) of plasma membranes and somatic hybridization between immunocompetent cells of the recipient and any cell of transplanted donor’s tissue, which may lead to the emergence of a cancer cell. Antibodies and lymphocytes can induce damages (perforations) of different degree on somatic cells plasma membranes.
Downloads
References
Engels E.A., Pfeiffer R.M., Fraumeni J.F. et al. – Spectrum of cancer risk among US solid organ transplant recipients. //JAMA, 2011, 306, p.1891-1901.
Kwak H.Y., Chae B.J., Bae J.S. et al. – Breast cancer after kidney transplantation: a single institution review. //World j. Surg. Oncol., 2013, 11, p.77.
Gogichadze G.K. – Views and suppositions about the pathogenesis of cancer. /Hamburg, disserta Verlag, 2016.
Gogichadze George D.K. – The paradoxical situation in carcinogenesis. Optimistic mistake or pessimistic truth? /Cambridge Scholars Publishing, 2020.
