PERPORATIONS OF PLASMA MEMBRANES, AS INITIAL STAGE OF TUMOR TRANSFORMATION

PERPORATIONS OF PLASMA MEMBRANES, AS INITIAL STAGE OF TUMOR TRANSFORMATION

Authors

  • T. GOGICHADZE
  • E. MISABISHVILI
  • G. GOGICHADZE

Abstract

Numerous carcinogenic substances and factors of different natures probably can signify that these carcino­gens must start up some common mechanism of normal cells transition into transformated states. Influence of physical, chemical and biological carcinogenic agents on cells probably are adequate. By our opinion the co­m­mon mechanism of action of diametrically different carcinogens on target-cells is the destruction of the pla­smatic membrane.  After influence of different carcinogens, cells’ fusion originates as a result of cytoplasmic membranes perforations, i.e. formation in plasma membranes pores, what induces alteration of summary su­perficial charge of cells’ surface. Because of this, cells acquire ability to approach each other, what in many cases may be a premise for fusion process. 

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References

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Published

2021-05-25

How to Cite

T. GOGICHADZE, E. MISABISHVILI, & G. GOGICHADZE. (2021). PERPORATIONS OF PLASMA MEMBRANES, AS INITIAL STAGE OF TUMOR TRANSFORMATION . Experimental and Clinical Medicine Georgia, (2). Retrieved from https://journals.4science.ge/index.php/jecm/article/view/337

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