PERPORATIONS OF PLASMA MEMBRANES, AS INITIAL STAGE OF TUMOR TRANSFORMATION
Abstract
Numerous carcinogenic substances and factors of different natures probably can signify that these carcinogens must start up some common mechanism of normal cells transition into transformated states. Influence of physical, chemical and biological carcinogenic agents on cells probably are adequate. By our opinion the common mechanism of action of diametrically different carcinogens on target-cells is the destruction of the plasmatic membrane. After influence of different carcinogens, cells’ fusion originates as a result of cytoplasmic membranes perforations, i.e. formation in plasma membranes pores, what induces alteration of summary superficial charge of cells’ surface. Because of this, cells acquire ability to approach each other, what in many cases may be a premise for fusion process.
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