THE MAIN APPROACHES TO THE TREATMENT OF THYMUS NEOPLASMS

ANZOR LAGVILAVA; DAVID GIORGADZE; GIORGI CHADUNELI

doi:10.52340/jecm.2023.06.01

THE MAIN APPROACHES TO THE TREATMENT OF THYMUS NEOPLASMS

Authors

ANZOR LAGVILAVA
DAVID GIORGADZE
GIORGI CHADUNELI

DOI:

https://doi.org/10.52340/jecm.2023.06.01

Keywords:

tumors, thymus gland, video thoracoscopy, sternotomy, thymectomy

Abstract

The treatment of thymus neoplasms is an urgent problem due to the heterogeneous nature of tumors, diverse clinical presentation, and molecular genetic features of tumors. The "gold standard" is considered to be total thymectomy, which technically should be performed from any access chosen by the operating surgeon to improve survival rates and quality of life of patients. The development of technical progress and the introduction of minimally invasive techniques into the surgical practice of thoracic surgeons (video thoracoscopy, robotic-assisted interventions allow achieving better cosmetic effects, reducing the duration of hospitalization and minimizing the development of postoperative complications compared to median sternotomy. Further improvement of minimally invasive techniques is a promising direction in the treatment of thymus neoplasms, which allows to optimize the surgical stage of management of such patients.

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References

Scarpetta-Gonzalez, D.F., Morales, E.I., Sua, L.F. et al. Primary thymus tumors: retrospective case analysis at a reference center in Latin America, 2011–2019. BMC Cancer 21, 279 (2021).

Kuhn, E.; Pescia, C.; Mendogni, P.; Nosotti, M.; Ferrero, S. Thymic Epithelial Tumors: An Evolving Field. Life 2023, 13, 314. https://doi.org/10.3390/life13020314

Remon, J., Bernabé, R., Diz, P. et al. SEOM-GECP-GETTHI Clinical Guidelines for the treatment of patients with thymic epithelial tumours (2021). Clin Transl Oncol 24, 635–645 (2022).

Shao Y, Tang M, Fang L, Wei S, Gao X, Liu W. Prognostic value of tumor size in thymic epithelial tumors: A systematic review and meta-analysis. Medicine (Baltimore). 2022 Nov 18;101(46):e31741.

Pulle MV, Asaf BB, Puri HV, Bishnoi S, Kumar A. Meta-Analysis of Limited Thymectomy versus Total Thymectomy for Masaoka Stage I and II Thymoma. J Chest Surg. 2021 Apr 5;54(2):127-136.

Ashwini Arunachalam, Ina Zhang, Bin Zhao, Andrew M. Frederickson, M. Catherine Pietanza, Efficacy and safety of treatments for advanced thymic carcinoma after failure of first-line platinum-based chemotherapy: A systematic literature review and meta-analysis, Lung Cancer, 2023; 176:132-139, ISSN 0169-5002

Shao, Yifeng; Tang, Mingbo; Fang, Linan et al. Prognostic value of tumor size in thymic epithelial tumors: A systematic review and meta-analysis. Medicine 101(46):p e31741, November 18, 2022.

Chen H-F, Wu L-X, Li X-F, et al. PD-L1 expression level in different thymoma stages and thymic carcinoma: a meta-analysis. Tumori Journal. 2020;106(4):306-311.

Raza A, Woo E. Video-assisted thoracoscopic surgery versus sternotomy in thymectomy for thymoma and myasthenia gravis. Ann Cardiothorac Surg 2016; 5 (01):33-37.

Patel G, Reddy BVK, Patil P, Maximal Thymectomy via Mini Sternotomy with Pleural Preservation. South Asian J Cancer 2022;11(3):229-234.

Hsu CH, Chan JK, Yin CH, Lee CC, Chern CU, Liao CI. Trends in the incidence of thymoma, thymic carcinoma, and thymic neuroendocrine tumor in the United States. PLoS ONE 2019;14:e0227197.

Zaman M, Huissoon A, Buckland M, et al. Clinical and laboratory features of seventy-eight UK patients with Good's syndrome (thymoma and hypogammaglobulinaemia). Clin Exp Immunol 2019;195:132-8.

Funaki S, Shintani Y, Fukui E, Kanzaki R, Kanou T, Ose N, Minami M, Okumura M. Surgical treatment strategies for invasive thymoma. J Thorac Dis. 2020 Dec;12(12):7619-7625. doi: 10.21037/jtd-19-3045.

Fan, C., Ge, H., Zhang, S. et al. Impact of Definitive Radiotherapy and Surgical Debulking on Treatment Outcome and Prognosis for Locally Advanced Masaoka-Koga stage III Thymoma. Sci Rep 10, 1735 (2020).

Liu, Shuzhong; Zhou, Xi; Song, An; Huo, Zhen; Li, William A. Et al. Successful treatment of malignant thymoma with sacrum metastases: A case report and review of literature. Medicine 97(51):p e13796, Dec 2018.

Suster DI, Basu MK, Mackinnon AC. Molecular pathology of thymoma and thymic carcinoma. J Cancer Metastasis Treat 2022;8:19. http://dx.doi.org/10.20517/2394-4722.2021.210

Suster D, Mino-Kenudson M, Suster S. Diagnostic pathology: thoracic, 5th ed.; Philadelphia, PA:Eslevier; 2022

Zucali PA, De Vincenzo F, Perrino M, Digiacomo N, Cordua N, D'Antonio F, Borea F, Santoro A. Systemic treatments for thymic tumors: a narrative review. Mediastinum. 2021 Sep 25;5:24.

Aprile V, Bacchin D, Korasidis S, Ricciardi R, Petrini I et al. Hypertermic Intrathoracic Chemotherapy (HITHOC) for thymoma: a narrative review on indications and results. Ann Transl Med. 2021 Jun; 9(11):957.

Tseng Y-C, Hsieh C-C, Huang H-Y. et al. Is thymectomy necessary in nonmyasthenic patients with early thymoma?. J Thorac Oncol 2013; 8 (07) 952-958.

Zucali PA, De Pas T, Palmieri G, et al. Phase II study of everolimus in patients with thymoma and thymic carcinoma previously treated with cisplatin-based chemotherapy. J Clin Oncol. 2018; 36(4):342-349.

Hsu C-H, Chan JK, Yin C-H, Lee C-C, Chern C-U, Liao C-I (2019) Trends in the incidence of thymoma, thymic carcinoma, and thymic neuroendocrine tumor in the United States. PLoS ONE 14(12): e0227197.

Александров О.А., Рябов А.Б., Пикин О.В. Тимома (обзор литературы). Сибирский онкологический журнал. 2017; 16 (4): 76-83. DOI: 10.21294/1814-4861-2017-16-4-76-83.

Mehdi Alizadeh, Majid Vafaie, Saeid Tarlan, Hossein Moeini, Fatemeh Mohammadi Chelkassri, Mohammad Hosein Khoeiniha et al. Thymolipoma associated with lymphocytosis in a 6-year-old girl: A case report,Respiratory Medicine Case Reports, Volume 31, 2020, 101312, ISSN 22130071

Cong, L.; Wang, S.; Yeung, S.Y.; Lee, J.H.S.; Chung, J.P.W.; Chan, D.Y.L. Mature Cystic Teratoma: An Integrated Review. Int. J. Mol. Sci. 2023, 24, 6141.

Dhamija, A.; Kakuturu, J.; Hayanga, J.W.A.; Toker, A. Difficult Decisions in Minimally Invasive Surgery of the Thymus. Cancers 2021, 13, 5887. https://doi.org/10.3390/cancers13235887

Tianci, Chai; Shen, Zhimin; Chen, Sui et al. Median sternotomy versus minimally invasive thymectomy for early-stage thymoma: A systematic review and meta-analysis protocol. Medicine 98(51):p e18359, Dec 2019.

Lo, C.M. Thymectomy for myasthenia gravis: Video-assisted versus transsternal / C.M. Lo, H.I. Lu, M.J. Hsieh, S.S. Lee, J.P. Chang//Journal of the Formosan Medical Association. 2014; 113(10):722-726.

Li, Y. Left-sided approach video-assisted thymectomy for the treatment of thymic diseases / Y. Li, J. Wang//World Journal of Surgical Oncology. 2014; 12(1):1-7.

Chang Hyun Kang and others, The robotic thymectomy via the subxiphoid approach: technique and early outcomes, European Journal of Cardio-Thoracic Surgery, Volume 58, Issue Supplement-1, Aug 2020, i39–i43.