EFFECTS OF ORAL DEHYDROEPIANDROSTERONE (DHEA) SUPPLEMENTATION ON HORMONAL PROFILE AND MENOPAUSAL CLINICAL SYMPTOMS IN EARLY POSTMENOPAUSAL SYMPTOMATIC WOMEN
Keywords:Dehydroepiandrosterone, hormonal profile, menopausal clinical symptoms
Dehydroepiandrosterone (DHEA) and its sulfate (DHEAs) are steroid hormones secreted by the adrenal glands. The aging process is associated with decreased levels of DHEA and DHEAs, which are the initial causes of many age-related changes. We aimed to evaluate the effects of oral administration of DHEA (50mg/day) on hormonal profile, menopausal clinical symptoms and overall well-being in early postmenopausal symptomatic women. DHEA administration had a significant effect on certain endocrine parameters, was associated with improvements of menopausal physical symptoms, sexual function and psycho-emotional parameters. On this basis we can assume, that DHEA may be considered as a potentially effective medication for MHT. However, conducting further, more specific clinical trials are needed.
Andrea R. Genazzani, Nicola Pluchino et al. Long-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal women, Gynecological Endocrinology. 2006; 22(11):627-635, doi: 10.1080/09513590601024681
A. R. Genazzani, M. Stomati, V. Valentino, N. Pluchino, E. Potì, E. Casarosa, S. Merlini, A. Giannini and M. Luisi - Effect of 1-year, low-dose DHEA therapy on climacteric symptoms and female sexuality Article in Climacteric · September 2011 DOI: 10.3109/13697137.2011.579649 · Source: PubMed
Bill Lasley, Sybil L. Crawford, Gail A. Laughlin, et al. Circulating Dehydroepiandrosterone Sulfate Levels in Women with Bilateral Salpingo-Oophorectomy during the Menopausal Transition, Menopause. 2011 May; 18(5): 494–498. doi:10.1097/gme.0b013e3181fb53fc
M. Stomati, P. Monteleone, E. Casarosa, et al. Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause, Gynecological Endocrinology, 2000; 14(5):342-363. doi: 10.3109/09513590009167703
P. Stute, S. Bertschy, M. Birkhaeuser, J. Bitzer, A. Ging, A. Raggi, S. Steimann & V. Stute (2021): Swiss consensus on the role of DHEA in the management of genitourinary syndrome of menopause, Climacteric, DOI: 10.1080/13697137.2021.2008894